Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 377320..378107 | Replicon | chromosome |
| Accession | NZ_CP063878 | ||
| Organism | Klebsiella pneumoniae strain M169-3 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A377E3D6 |
| Locus tag | ISB47_RS02125 | Protein ID | WP_001194695.1 |
| Coordinates | 377730..378107 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | ISB47_RS02120 | Protein ID | WP_053266522.1 |
| Coordinates | 377320..377679 (+) | Length | 120 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ISB47_RS02075 (372559) | 372559..373011 | + | 453 | WP_001020418.1 | hypothetical protein | - |
| ISB47_RS02080 (373008) | 373008..373460 | + | 453 | WP_016245672.1 | hypothetical protein | - |
| ISB47_RS02085 (373523) | 373523..374065 | + | 543 | WP_001104018.1 | DUF4339 domain-containing protein | - |
| ISB47_RS02090 (374125) | 374125..374577 | + | 453 | WP_020837115.1 | IrmA family protein | - |
| ISB47_RS02095 (374654) | 374654..374887 | + | 234 | WP_001114682.1 | DUF905 domain-containing protein | - |
| ISB47_RS02100 (375007) | 375007..375825 | + | 819 | WP_001614356.1 | DUF932 domain-containing protein | - |
| ISB47_RS02105 (376093) | 376093..376563 | + | 471 | WP_000131762.1 | antirestriction protein | - |
| ISB47_RS02110 (376575) | 376575..377054 | + | 480 | WP_000437750.1 | DNA repair protein RadC | - |
| ISB47_RS02115 (377075) | 377075..377296 | + | 222 | WP_044068431.1 | DUF987 domain-containing protein | - |
| ISB47_RS02120 (377320) | 377320..377679 | + | 360 | WP_053266522.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| ISB47_RS02125 (377730) | 377730..378107 | + | 378 | WP_001194695.1 | TA system toxin CbtA family protein | Toxin |
| ISB47_RS02130 (378104) | 378104..378595 | + | 492 | WP_000777682.1 | DUF5983 family protein | - |
| ISB47_RS02135 (378635) | 378635..378829 | + | 195 | WP_032155094.1 | DUF957 domain-containing protein | - |
| ISB47_RS02140 (378910) | 378910..379754 | + | 845 | Protein_426 | DUF4942 domain-containing protein | - |
| ISB47_RS02150 (380098) | 380098..380829 | - | 732 | WP_004152034.1 | DNA polymerase III subunit epsilon | - |
| ISB47_RS02155 (380894) | 380894..381361 | + | 468 | WP_002889686.1 | ribonuclease HI | - |
| ISB47_RS02160 (381358) | 381358..382080 | - | 723 | WP_032419379.1 | class I SAM-dependent methyltransferase | - |
| ISB47_RS02165 (382113) | 382113..382868 | + | 756 | WP_032419380.1 | hydroxyacylglutathione hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14180.97 Da Isoelectric Point: 7.4209
>T179140 WP_001194695.1 NZ_CP063878:377730-378107 [Klebsiella pneumoniae]
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR
Download Length: 378 bp
>T179140 NZ_CP084592:c864107-863802 [Mycobacterium intracellulare subsp. chimaera]
GTGATCACACCCGGAGACATCACGCCAGGCCGCGACACCAACCAGGAACTGTACGTTGTCGTACTATCTAACACGATTCA
CCTCGCAGCCGCCACCGGCCAGGTGATCATCTGCCCCTTCATTCCCGGTGAAATCCCCAGCAGCACAATGGCTATGATCG
TCACAGTGCTGCAACCCAAAGGGGTTGTCTTACCGGAGCTCATCCAGTGGCTTCCTGTCGCGGCCCTCGACCAACCCATC
GGCAATATCGGCGGCATCGCGCTCGCTGACACGACCACGACCGCCGTCACCGCGCTCATTTCCTGA
GTGATCACACCCGGAGACATCACGCCAGGCCGCGACACCAACCAGGAACTGTACGTTGTCGTACTATCTAACACGATTCA
CCTCGCAGCCGCCACCGGCCAGGTGATCATCTGCCCCTTCATTCCCGGTGAAATCCCCAGCAGCACAATGGCTATGATCG
TCACAGTGCTGCAACCCAAAGGGGTTGTCTTACCGGAGCTCATCCAGTGGCTTCCTGTCGCGGCCCTCGACCAACCCATC
GGCAATATCGGCGGCATCGCGCTCGCTGACACGACCACGACCGCCGTCACCGCGCTCATTTCCTGA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13109.09 Da Isoelectric Point: 7.3717
>AT179140 WP_053266522.1 NZ_CP063878:377320-377679 [Klebsiella pneumoniae]
MSNKTPIVNHDITEPWWGLKRSITPCFGARLVQAGNCLHYLADRASITGQFSDAVLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA
MSNKTPIVNHDITEPWWGLKRSITPCFGARLVQAGNCLHYLADRASITGQFSDAVLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA
Download Length: 360 bp
>AT179140 NZ_CP084592:c864331-864104 [Mycobacterium intracellulare subsp. chimaera]
ATGGCGAAAGCCAAAGTGTCCGTAATGATTGAAGAGGCCGTGCTGGCGGCGGCCGATGCGGACGCCCAGGCGGCCGGGCT
GAATCGTTCAGAGATGATCGAACGAGCCCTGCACAACGAGCATCTCCGAATCTCGCTCGAGAACTACACAACACACACTG
TGCCAACGCTCGACATCGACGCCTACGCGGAGAAGATCTATCAGGCGAACCGGGCCGCTGGCCTGTGA
ATGGCGAAAGCCAAAGTGTCCGTAATGATTGAAGAGGCCGTGCTGGCGGCGGCCGATGCGGACGCCCAGGCGGCCGGGCT
GAATCGTTCAGAGATGATCGAACGAGCCCTGCACAACGAGCATCTCCGAATCTCGCTCGAGAACTACACAACACACACTG
TGCCAACGCTCGACATCGACGCCTACGCGGAGAAGATCTATCAGGCGAACCGGGCCGCTGGCCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|