Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Hha-TomB/- |
| Location | 124783..125402 | Replicon | chromosome |
| Accession | NZ_CP063878 | ||
| Organism | Klebsiella pneumoniae strain M169-3 | ||
Toxin (Protein)
| Gene name | Hha | Uniprot ID | R8WYV2 |
| Locus tag | ISB47_RS00860 | Protein ID | WP_002892050.1 |
| Coordinates | 125184..125402 (+) | Length | 73 a.a. |
Antitoxin (Protein)
| Gene name | TomB | Uniprot ID | J2DPF6 |
| Locus tag | ISB47_RS00855 | Protein ID | WP_002892066.1 |
| Coordinates | 124783..125157 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ISB47_RS00845 (119935) | 119935..121128 | + | 1194 | WP_004177236.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
| ISB47_RS00850 (121151) | 121151..124297 | + | 3147 | WP_002892069.1 | multidrug efflux RND transporter permease subunit AcrB | - |
| ISB47_RS00855 (124783) | 124783..125157 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
| ISB47_RS00860 (125184) | 125184..125402 | + | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
| ISB47_RS00865 (125561) | 125561..126127 | + | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
| ISB47_RS00870 (126099) | 126099..126239 | - | 141 | WP_004147370.1 | hypothetical protein | - |
| ISB47_RS00875 (126260) | 126260..126730 | + | 471 | WP_002892026.1 | YlaC family protein | - |
| ISB47_RS00880 (126705) | 126705..128156 | - | 1452 | WP_032419337.1 | PLP-dependent aminotransferase family protein | - |
| ISB47_RS00885 (128257) | 128257..128955 | + | 699 | WP_002892021.1 | GNAT family protein | - |
| ISB47_RS00890 (128952) | 128952..129092 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
| ISB47_RS00895 (129092) | 129092..129355 | - | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T179139 WP_002892050.1 NZ_CP063878:125184-125402 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T179139 NZ_CP084592:c288098-287538 [Mycobacterium intracellulare subsp. chimaera]
GTGAGCGATGCCCTCGACGAAGGGCTCGTCCAGCGCATCGACGCATGCGGCACCACTCCGTGGTCAGGCACGTGCTATCG
GTACACGACAGCTCATCGCGACGCACTCTCCGGCGAAGGCGCACGACGGTTCGGTGGCCGATGGAACCCACCACTGCTCT
TCCCCGCCATCTACCTTGCCGACTCCGCCAAGGCTTGCATGGTCGAAGTCGAACGCGCCGCCAACGCGGCCTCCACCACC
GCAATAAAGATGCTGGAGGCGGCCTACCGACTGCACCACATCCAGGTCGAGGAACTCAACGTTCTCGACTTGCGCACACC
CGAATCTCGAGACGCCGTCGGTCTCGACGACGACGACGTCTACGGTGACGACTGGTCCGCCTGCCAAGCAGTCGGACACA
CCGCCTGGTTCCTGCACATGCAAGGGATCCTGGTCCCCGCCGCCGGCGGCATCGGCCTCGTCATCTCCGCCTATGAACAG
CGAACGCGCCCAAGACAACTGCATCTCAGGCACAGCGAAAACCTCACCCCGGCGCTCTACACCCAATACCGCTCCAGCTA
A
GTGAGCGATGCCCTCGACGAAGGGCTCGTCCAGCGCATCGACGCATGCGGCACCACTCCGTGGTCAGGCACGTGCTATCG
GTACACGACAGCTCATCGCGACGCACTCTCCGGCGAAGGCGCACGACGGTTCGGTGGCCGATGGAACCCACCACTGCTCT
TCCCCGCCATCTACCTTGCCGACTCCGCCAAGGCTTGCATGGTCGAAGTCGAACGCGCCGCCAACGCGGCCTCCACCACC
GCAATAAAGATGCTGGAGGCGGCCTACCGACTGCACCACATCCAGGTCGAGGAACTCAACGTTCTCGACTTGCGCACACC
CGAATCTCGAGACGCCGTCGGTCTCGACGACGACGACGTCTACGGTGACGACTGGTCCGCCTGCCAAGCAGTCGGACACA
CCGCCTGGTTCCTGCACATGCAAGGGATCCTGGTCCCCGCCGCCGGCGGCATCGGCCTCGTCATCTCCGCCTATGAACAG
CGAACGCGCCCAAGACAACTGCATCTCAGGCACAGCGAAAACCTCACCCCGGCGCTCTACACCCAATACCGCTCCAGCTA
A
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT179139 WP_002892066.1 NZ_CP063878:124783-125157 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT179139 NZ_CP084592:c288436-288095 [Mycobacterium intracellulare subsp. chimaera]
ATGGCAATGAATGCGCTCGCCTCGACCGTTTCGAGCGCCATCGAACGCCTGGGACTCACCTACGAAGAAGTCGGAGACAT
CGTCGAGGCCTCCCCACGCTCCGTGGCGCGGTGGACGTCGGGCCAAGTAGTTCCACAACGACTAAACAAGCAACGTCTGA
TCGAACTGGCTTACGTTGCCGATGCCCTTGCCGAAGTCCTCCCTCGCGACCAGGCGAATATGTGGATGTTCTCGCCGAAC
CGACTACTAGAGCACCGCAAGCCGGCCGACCTCATCCGAGATGGCGAATACCAGCGAGTGCTAGCCCTCATCGACGCCAT
GGCCGAGGGAGTGTTCGTGTGA
ATGGCAATGAATGCGCTCGCCTCGACCGTTTCGAGCGCCATCGAACGCCTGGGACTCACCTACGAAGAAGTCGGAGACAT
CGTCGAGGCCTCCCCACGCTCCGTGGCGCGGTGGACGTCGGGCCAAGTAGTTCCACAACGACTAAACAAGCAACGTCTGA
TCGAACTGGCTTACGTTGCCGATGCCCTTGCCGAAGTCCTCCCTCGCGACCAGGCGAATATGTGGATGTTCTCGCCGAAC
CGACTACTAGAGCACCGCAAGCCGGCCGACCTCATCCGAGATGGCGAATACCAGCGAGTGCTAGCCCTCATCGACGCCAT
GGCCGAGGGAGTGTTCGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2P8K6F2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GJ93 |