179138

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 80604..81514 Replicon plasmid pS174-1.3
Accession NZ_CP063877
Organism Klebsiella quasipneumoniae strain S174-1

Toxin (Protein)


Gene name - Uniprot ID R4YBC5
Locus tag IOD26_RS27490 Protein ID WP_004144067.1
Coordinates 80604..81074 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6A8PHD0
Locus tag IOD26_RS27495 Protein ID WP_023287184.1
Coordinates 81071..81514 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD26_RS27470 76830..77798 - 969 WP_074423483.1 IS5 family transposase -
IOD26_RS27475 78103..78363 + 261 WP_017901409.1 hypothetical protein -
IOD26_RS27480 78552..79520 - 969 WP_072096747.1 IS5 family transposase -
IOD26_RS27485 79522..80517 - 996 WP_077254794.1 IS5 family transposase -
IOD26_RS27490 80604..81074 - 471 WP_004144067.1 RES family NAD+ phosphorylase Toxin
IOD26_RS27495 81071..81514 - 444 WP_023287184.1 DUF2384 domain-containing protein Antitoxin
IOD26_RS27500 81615..82763 - 1149 Protein_90 translesion error-prone DNA polymerase V subunit UmuC -
IOD26_RS27505 82810..84297 - 1488 Protein_91 Mov34/MPN/PAD-1 family protein -
IOD26_RS27510 84352..85320 - 969 WP_074424072.1 IS5 family transposase -
IOD26_RS27515 85349..86098 - 750 Protein_93 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B - 1..159310 159310
- inside IScluster/Tn - - 56268..88242 31974


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17573.83 Da        Isoelectric Point: 4.5152

>T179138 WP_004144067.1 NZ_CP063877:c81074-80604 [Klebsiella quasipneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T179138 NZ_CP084588:78549-78806 [Mycobacterium intracellulare subsp. chimaera]
GTGAGAAGCATCAACTTCGATCCCGCCGCGTGGGAGGACTTTCTATTTTGGCTGGCTTCCGACCGCAAAACAGCACGGCG
CATCACCAGACTCATCGCAGAAATCCAGCGCAACCCGTTTGCTGGGATTGGAAAACCAGAACCGCTCAAGGGTGAACTAT
CCGGGTACTGGTCGCGGCGCATCGACGACGAACACCGGATCGTCTACCGCGCAGATGATCACGAAATCAAGATCCTCAAA
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16522.84 Da        Isoelectric Point: 10.3013

>AT179138 WP_023287184.1 NZ_CP063877:c81514-81071 [Klebsiella quasipneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT179138 NZ_CP084588:78268-78552 [Mycobacterium intracellulare subsp. chimaera]
ATGGCTATCAGTGCAAGTGAGGCCCGGCAGCGCCTCTTTCCGCTGCTTGAACAAGTCAACACCGACCACGAGCCTGTGCG
AATTACGTCCAAGGCCGGAGATGCAGTGCTCATGTCGGCCGCTGACTACGATTCGTGGCAAGAAACGGTCTACCTCCTGC
GTTCCCCCGAGAATGCCCGCCGACTCATGGAGGCCGTCGCCCGAGACAACGCCACCCGGCCCACCCCCGGCAGCTACACC
AAGTCGATCGACGAACTCGAGGAGATGGCCGGCGGCCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A384IED8

Antitoxin

Source ID Structure
AlphaFold DB A0A6A8PHD0

References