179134

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 46524..47046 Replicon plasmid pS174-1.1
Accession NZ_CP063875
Organism Klebsiella quasipneumoniae strain S174-1

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag IOD26_RS26670 Protein ID WP_000220561.1
Coordinates 46524..46805 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag IOD26_RS26675 Protein ID WP_000121743.1
Coordinates 46795..47046 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD26_RS26640 42000..42236 - 237 Protein_45 hypothetical protein -
IOD26_RS26645 42257..43051 - 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
IOD26_RS26650 43080..44510 - 1431 Protein_47 IS4-like element IS50R family transposase -
IOD26_RS26655 44630..44818 + 189 WP_000957857.1 hypothetical protein -
IOD26_RS26660 44828..46027 + 1200 WP_000948429.1 IS91 family transposase -
IOD26_RS26665 46193..46285 + 93 Protein_50 IS6 family transposase -
IOD26_RS26670 46524..46805 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IOD26_RS26675 46795..47046 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
IOD26_RS26680 48281..49120 + 840 WP_024129959.1 replication initiation protein -
IOD26_RS26685 49141..49983 + 843 WP_063116919.1 replication initiation protein -
IOD26_RS26690 49987..50433 + 447 WP_001074384.1 hypothetical protein -
IOD26_RS26695 50501..50923 + 423 WP_179292036.1 DNA distortion polypeptide 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / qepA1 / blaCTX-M-65 / dfrA14 / ant(3'')-Ia / blaOXA-10 / cmlA1 / ARR-3 / tet(A) / aph(3')-IIa - 1..51856 51856


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T179134 WP_000220561.1 NZ_CP063875:c46805-46524 [Klebsiella quasipneumoniae]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T179134 NZ_CP084586:2798706-2799284 [Mycobacterium intracellulare subsp. chimaera]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAAATCGCAAGGCAGCGCTGGCCGGAGGAGTCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGACACGCGCGCGAAGTTGATCGACCTGGGTCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTGTCCGACGTCGCCACCGTCTACGACAACAGCCGGCTGCGCGGG
CCGCGCATCGTCGCCCGCCTCACCGGCGGCATGACAATCGGTTCACCGGACTGGCCCGCGTGGACGCCAGGGACCTTGCG
GTCACGCTGGGCGGACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT179134 WP_000121743.1 NZ_CP063875:c47046-46795 [Klebsiella quasipneumoniae]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT179134 NZ_CP084586:2798292-2798681 [Mycobacterium intracellulare subsp. chimaera]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGATGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCGGCTATTGAAGAAAGCCTGGTGCACGCCAACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References