Detailed information of TA system TA179133

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 5336853..5338441
• Replicon: chromosome
• Accession: NZ_CP063874
• Organism: Klebsiella quasipneumoniae strain S174-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A246AZS4
• Locus tag: IOD26_RS26165
• Protein ID: WP_017900381.1
• Coordinates: 5336853..5338175 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IOD26_RS26170
• Protein ID: WP_117131371.1
• Coordinates: 5338175..5338441 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IOD26_RS26130	5331935..5332153	+	219	WP_002904808.1	ParD-like family protein	-
IOD26_RS26135	5332134..5332916	+	783	WP_048294851.1	type I methionyl aminopeptidase	-
IOD26_RS26140	5333185..5334300	+	1116	WP_200982855.1	serine hydrolase	-
IOD26_RS26145	5334287..5334631	+	345	WP_004205915.1	hypothetical protein	-
IOD26_RS26150	5334660..5335193	+	534	WP_004205916.1	hypothetical protein	-
IOD26_RS26155	5335196..5335402	+	207	WP_004205917.1	helix-turn-helix transcriptional regulator	-
IOD26_RS26160	5335544..5336836	+	1293	WP_023318214.1	glycoside hydrolase family 10 protein	-
IOD26_RS26165	5336853..5338175	-	1323	WP_017900381.1	type II toxin-antitoxin system HipA family toxin	Toxin
IOD26_RS26170	5338175..5338441	-	267	WP_117131371.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
IOD26_RS26175	5338724..5339050	-	327	WP_064187240.1	hydroxyisourate hydrolase	-
IOD26_RS26180	5339047..5339547	-	501	WP_004205925.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
IOD26_RS26185	5339525..5340904	-	1380	WP_017900377.1	purine permease	-
IOD26_RS26190	5341250..5342404	+	1155	WP_004205928.1	FAD-dependent urate hydroxylase HpxO	-
IOD26_RS26195	5342385..5343308	-	924	WP_146410783.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-68)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49041.33 Da
• Isoelectric Point: 8.6091

>T179133 WP_017900381.1 NZ_CP063874:c5338175-5336853 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARRTLPSDFSAHVWRAITENMLKLHARLQQGLQAG

Nucleotide

• Length: 1323 bp

>T179133 NZ_CP084586:2467466-2467873 [Mycobacterium intracellulare subsp. chimaera]
ATGAGCAACCCGCAGGTGGCCGGAGTGCTCGACACTTCGGTGTTCATCGCGACCGAAAGTGGTCGGCCTCTCGACGCGGC
GCTGATCCCTGATCAAGTTGGCACTACGGTTGTTACCCTCGCGGAACTGCACGTTGGTGTGTTGGCCGCGTCGACTTCCG
ATATTAGAGCGCAGCGCCTCGCGACATTGGAATCCATTGCGGATATCGAAGCGCTGCCGGTCGATGACGATGCGGCCCGG
ATGTGGGCCCGGCTGCGGATCCATCTCGCCGAGACCGGTCAACGCGTCCGGATCAACGATCTGTGGATCGCGGCCATCGC
GGCGTCCCGAGGGCTACCTGTTGTCACGCAGGACGATGACTTTGCCGTCTTGGATGGTGCGGCCAATTTGACCGTTATCC
GCGTCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9912.33 Da
• Isoelectric Point: 7.1997

>AT179133 WP_117131371.1 NZ_CP063874:c5338441-5338175 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVAMTLNAKPAETAMIP
DNTTDLDW

Nucleotide

• Length: 267 bp

>AT179133 NZ_CP084586:2467209-2467469 [Mycobacterium intracellulare subsp. chimaera]
ATGTCTGAAGTGGCATCTCGTGAGCTGCGCAACGATACGGCTGGGGTGCTGCGGCGGGTTCGGGATGGAGAGGACGTCAC
CATCACTGTCAGTGGCCGACCGGTCGCAGTTCTTACCGCAGTTGTCCCTCAGCGCAGGCGTTGGCTGAGCAAGACGGAGT
TGCTGTCGCGCTTGCCCCGCGTTCAAGCGGATCCGGGATTACGCGAGGACCTTCACGCACTCGCCGGCGACACTACCGAG
GAGCTGGGCCCGATCCGATGA

Structures

Toxin

• AlphaFold DB: A0A246AZS4