Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3516759..3517560 Replicon chromosome
Accession NZ_CP063874
Organism Klebsiella quasipneumoniae strain S174-1

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag IOD26_RS17160 Protein ID WP_061891985.1
Coordinates 3517174..3517560 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag IOD26_RS17155 Protein ID WP_061891986.1
Coordinates 3516759..3517118 (+) Length 120 a.a.

Genomic Context

IOD26_RS17125IOD26_RS17130IOD26_RS17135IOD26_RS17140IOD26_RS17145IOD26_RS17150IOD26_RS17155IOD26_RS17160IOD26_RS17165IOD26_RS17175IOD26_RS17170IOD26_RS17180
Location: 3512357..3513307 (951 bp)
Type: Others
Protein ID: WP_065802137.1
Location: 3513515..3514483 (969 bp)
Type: Others
Protein ID: WP_000654811.1
Location: 3514705..3515526 (822 bp)
Type: Others
Protein ID: WP_101991335.1
Location: 3515559..3516008 (450 bp)
Type: Others
Protein ID: WP_061891987.1
Location: 3516020..3516499 (480 bp)
Type: Others
Protein ID: WP_029504112.1
Location: 3516513..3516734 (222 bp)
Type: Others
Protein ID: WP_004192297.1
Location: 3516759..3517118 (360 bp)
Type: Antitoxin
Protein ID: WP_061891986.1
Location: 3517174..3517560 (387 bp)
Type: Toxin
Protein ID: WP_061891985.1
Location: 3517647..3518486 (840 bp)
Type: Others
Protein ID: WP_000918387.1
Location: 3520345..3521262 (918 bp)
Type: Others
Protein ID: WP_004205331.1
Location: 3518827..3520215 (1389 bp)
Type: Others
Protein ID: WP_182949436.1
Location: 3521510..3522313 (804 bp)
Type: Others
Protein ID: WP_048295568.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IOD26_RS171253512357..3513307+951WP_065802137.1hypothetical protein-
IOD26_RS171303513515..3514483+969WP_000654811.1IS5 family transposase-
IOD26_RS171353514705..3515526+822WP_101991335.1DUF945 domain-containing protein-
IOD26_RS171403515559..3516008+450WP_061891987.1antirestriction protein-
IOD26_RS171453516020..3516499+480WP_029504112.1DNA repair protein RadC-
IOD26_RS171503516513..3516734+222WP_004192297.1DUF987 domain-containing protein-
IOD26_RS171553516759..3517118+360WP_061891986.1type IV toxin-antitoxin system YeeU family antitoxinAntitoxin
IOD26_RS171603517174..3517560+387WP_061891985.1TA system toxin CbtA family proteinToxin
IOD26_RS171653517647..3518486+840WP_000918387.1DUF4942 domain-containing protein-
IOD26_RS171703518827..3520215-1389WP_182949436.1MFS transporter-
IOD26_RS171753520345..3521262+918WP_004205331.1LysR family transcriptional regulator-
IOD26_RS171803521510..3522313-804WP_048295568.1carboxymuconolactone decarboxylase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--3513560..3514483923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(8-110)

Antitoxin

Antitoxin CbeA

(16-114)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14346.48 Da        Isoelectric Point: 9.9973

>T179124 WP_061891985.1 NZ_CP063874:3517174-3517560 [Klebsiella quasipneumoniae]
MQTKLPFMRVASSRPSPVGVWQTLLTCLLAHHYGLTLNDTPFSDEQVIQQHIDAGISLVDALNFIVEKYELVRTDRPGFS
IREQSPFITPIDILRARKATGLMNRGTYKEVTAITRGQHPQANASGKR

Download         Length: 387 bp

>T179124 NZ_CP084581:3218946-3219872 [Aeromonas hydrophila]
ATGAATAAAGACTCAGTCTATTACCGACAGGTACAATTACTGCTCAAGATGCTGCCAGTCATCGCCAATGAGAAGATGTT
TGCCCTAAAAGGGGGAACTGCTATCAATCTTTTTGTACGTGAGTTCCCCCGACTGTCTGTTGATATCGATTTATCTTATC
TGCCACTCGAGCCTCGAGAAGAAGCGATAGCCAATGTCAGGGCCGCATTGCAGCGGATTGTCGAACAAACGAATAAGCAA
CAAGGCCTACAAGCCCGTCTTCAAGACAATAACGGGGATGAACTCAGGATTATCGTCACAGGAGCTGCGACGATCAAAAT
CGAACTCTCGCCAGTTGCCCGAGGTACACTACATGACCCCGAAGTGCTTCCTGTGGTTGAAGATGTCGAAACTGAGTTTG
GCTACGCCGAAATAGCAGTTGTCAGCATGCCTGACCTTTACGGGGGCAAACTCTGTGCTGCAATGGACAGACAACACCCA
CGGGATCTGTTTGATGTCCGAATGCTATTGGCTGCAGAGGGGATAACCCGGGAGATATTTGTGGGCTTCCTCGCTTACAC
TCTGGGCCATCCCAGACCGATCAGCGAAGTAATGGACCCAAGATGGAAAGATCTCTCTGGCGCGTTTCAACAGGAGTTTG
AAGGGATGACTAACGAACCCGTCACCTTGGAGGAGCTGCTTGAAGTCCCCGAAGCAATGTTTGCCGCTTTAAAAGCCCAG
TTTACCCCACGCGATAAAGACTTTCTCCTATCCTTCAAACGAGGAGAGCCTGACTGGACACTGTTTGATGTACCTACCGC
AGAGCGGTTACCCGCGATTCGTTGGAAACTACAGAATTTGCAAAAGCTACGAGAACGCACCCCTGAAAAACATCAAGAGA
CATTGGGAAAACTCGACAAGCTCCTAACGACATGGCTTGCTGAATAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13373.16 Da        Isoelectric Point: 6.7392

>AT179124 WP_061891986.1 NZ_CP063874:3516759-3517118 [Klebsiella quasipneumoniae]
MSKKTTIATHDISESWWGLRRSVSACFGARLVQEGNRLHYLADRANFDGQFCDADLRHLDQSFPVLMKQLELLLTSGELN
PRHQHCVTLYAKGLTCEADTLGSHGYVYIAIYSTPIATE

Download         Length: 360 bp

>AT179124 NZ_CP084581:3218165-3218953 [Aeromonas hydrophila]
ATATCATCAAAGATAAACTGGCTAGCCAACCACGCCCCACCCGGTTCGTTGGTGCTGCAACCATGGCTCATAGAAAACGG
TATCAGCTACTCCTTGGCATCTAAGTATGCAAACAGCGGTTGGTTGAAAAAAATGACCAACGGCGTCTACTACCGCCCTA
ATCCCTATCAGAATTCACTACCTGATTGGACTGATGCTCTCGCAGCCATCACCAATCAACTGAATCGCCATCCCCACATA
GCAGGTCTCACAAGCCTGAAATACCAAGGACTAAGTCACTATCTGCAACTCGGAAAAGAGCAGGTCTGGCTCGGTGGTGA
GAGTAAGAGCTCTCTCCCAGCATGGTTTCGTGAGTTTGACTGCTCACCCTGGTTGTTTATCGGCACATCGAAACTGGCAG
CGCAAAGCGAAAAAGATTTCACACTGATCACTGTACAGGGCAAAGAACTCCGAGCCAGCTGCCCCGAACTCGCCGCATAT
GAGGTAGTAAACTCGATAGGTAAACATATTAGCTTTGAGCATGCTGCGGATCTGTTTCAAGGATTGACTAATTTGAGTCC
TCGTAAAGTGCAATCCATATTGACACGGAGCAAGGCAGTCCAAACCAATCGGGTATTTCTTTTTCTCTCCCATTATTATC
GCCATCAGTGGACAAAGAGACTCGATGAAACCCAGATCACATTGGGAACCGGCAAACGCCAAGTTGTCGCACAAGGGCGG
TTAGAACCTCGCTATCAAATCACCGTGCCAGAACCTTTTTTCGTAGCATCAGAGATCGATCATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References