Detailed information of TA system TA179123

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3482575..3483232
• Replicon: chromosome
• Accession: NZ_CP063874
• Organism: Klebsiella quasipneumoniae strain S174-1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: IOD26_RS16990
• Protein ID: WP_194007124.1
• Coordinates: 3482822..3483232 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: IOD26_RS16985
• Protein ID: WP_002916312.1
• Coordinates: 3482575..3482841 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IOD26_RS16960	3477783..3479216	-	1434	WP_049004121.1	6-phospho-beta-glucosidase BglA	-
IOD26_RS16965	3479335..3480063	-	729	WP_004205316.1	MurR/RpiR family transcriptional regulator	-
IOD26_RS16970	3480114..3480425	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
IOD26_RS16975	3480588..3481247	+	660	WP_004205319.1	hemolysin III family protein	-
IOD26_RS16980	3481346..3482329	-	984	WP_017899798.1	tRNA-modifying protein YgfZ	-
IOD26_RS16985	3482575..3482841	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
IOD26_RS16990	3482822..3483232	+	411	WP_194007124.1	protein YgfX	Toxin
IOD26_RS16995	3483239..3483760	-	522	WP_004205324.1	flavodoxin FldB	-
IOD26_RS17000	3483861..3484757	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
IOD26_RS17005	3484780..3485493	+	714	WP_004205326.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
IOD26_RS17010	3485499..3487232	+	1734	WP_004205327.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16049.85 Da
• Isoelectric Point: 11.4778

>T179123 WP_194007124.1 NZ_CP063874:3482822-3483232 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILATPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T179123 NZ_CP084578:c2297589-2297305 [Sulfurimonas sp. SWIR-19]
ATGAGCTTATATAGGCTGCAATTTACAAAAAATGCAAAAAAAGAGTGGGACAAATTAGACCATTCTATTCAATTGCAATT
GCACAAAAAGCTCAAACAGCGTTTACAAAATCCAAAAGTTCCAAGTGCAAAGTTAAGTGGTTTTGATAATGTTTACAAGA
TAAAACTTCGAAATTCAGGATATCGACTAGCCTATGAAGTAAAAGATGTCGAAATCATTGTAATAGTATTAAAAATTGGT
AAGAGAGAAAACTTTTATGAACTGTTACGAGATTTTTTGAAATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT179123 WP_002916312.1 NZ_CP063874:3482575-3482841 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT179123 NZ_CP084578:c2297833-2297576 [Sulfurimonas sp. SWIR-19]
ATGAAACAGATTTTAGCAAATTATACAGCGAGCATTACCGAGTTGAAAAAATCACCTACAAAACTGCTGGATGAGGCTGG
TAATGAGCCTATCGCAATTTTGAATCATAATACACCAAGTGCTTATCTTGTGCCCAGCAGTTACTATGAAAAAATAATGG
ACATTCTCGATGAGCATTATTTGGAAAAAGAGGTAAAAGAAGCATTGAACTATAGCAAGGATGAACTCGTAGAGGTTGAT
ATAGATGAGCTTATATAG

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41