Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3482575..3483232 Replicon chromosome
Accession NZ_CP063874
Organism Klebsiella quasipneumoniae strain S174-1

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag IOD26_RS16990 Protein ID WP_194007124.1
Coordinates 3482822..3483232 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IOD26_RS16985 Protein ID WP_002916312.1
Coordinates 3482575..3482841 (+) Length 89 a.a.

Genomic Context

IOD26_RS16970IOD26_RS16975IOD26_RS16985IOD26_RS16990IOD26_RS17000IOD26_RS17005IOD26_RS17010IOD26_RS16960IOD26_RS16965IOD26_RS16980IOD26_RS16995
Location: 3480114..3480425 (312 bp)
Type: Others
Protein ID: WP_004144734.1
Location: 3480588..3481247 (660 bp)
Type: Others
Protein ID: WP_004205319.1
Location: 3482575..3482841 (267 bp)
Type: Antitoxin
Protein ID: WP_002916312.1
Location: 3482822..3483232 (411 bp)
Type: Toxin
Protein ID: WP_194007124.1
Location: 3483861..3484757 (897 bp)
Type: Others
Protein ID: WP_004144729.1
Location: 3484780..3485493 (714 bp)
Type: Others
Protein ID: WP_004205326.1
Location: 3485499..3487232 (1734 bp)
Type: Others
Protein ID: WP_004205327.1
Location: 3477783..3479216 (1434 bp)
Type: Others
Protein ID: WP_049004121.1
Location: 3479335..3480063 (729 bp)
Type: Others
Protein ID: WP_004205316.1
Location: 3481346..3482329 (984 bp)
Type: Others
Protein ID: WP_017899798.1
Location: 3483239..3483760 (522 bp)
Type: Others
Protein ID: WP_004205324.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IOD26_RS169603477783..3479216-1434WP_049004121.16-phospho-beta-glucosidase BglA-
IOD26_RS169653479335..3480063-729WP_004205316.1MurR/RpiR family transcriptional regulator-
IOD26_RS169703480114..3480425+312WP_004144734.1N(4)-acetylcytidine aminohydrolase-
IOD26_RS169753480588..3481247+660WP_004205319.1hemolysin III family protein-
IOD26_RS169803481346..3482329-984WP_017899798.1tRNA-modifying protein YgfZ-
IOD26_RS169853482575..3482841+267WP_002916312.1FAD assembly factor SdhEAntitoxin
IOD26_RS169903482822..3483232+411WP_194007124.1protein YgfXToxin
IOD26_RS169953483239..3483760-522WP_004205324.1flavodoxin FldB-
IOD26_RS170003483861..3484757+897WP_004144729.1site-specific tyrosine recombinase XerD-
IOD26_RS170053484780..3485493+714WP_004205326.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
IOD26_RS170103485499..3487232+1734WP_004205327.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179123 WP_194007124.1 NZ_CP063874:3482822-3483232 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILATPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179123 NZ_CP084578:c2297589-2297305 [Sulfurimonas sp. SWIR-19]
ATGAGCTTATATAGGCTGCAATTTACAAAAAATGCAAAAAAAGAGTGGGACAAATTAGACCATTCTATTCAATTGCAATT
GCACAAAAAGCTCAAACAGCGTTTACAAAATCCAAAAGTTCCAAGTGCAAAGTTAAGTGGTTTTGATAATGTTTACAAGA
TAAAACTTCGAAATTCAGGATATCGACTAGCCTATGAAGTAAAAGATGTCGAAATCATTGTAATAGTATTAAAAATTGGT
AAGAGAGAAAACTTTTATGAACTGTTACGAGATTTTTTGAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179123 WP_002916312.1 NZ_CP063874:3482575-3482841 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179123 NZ_CP084578:c2297833-2297576 [Sulfurimonas sp. SWIR-19]
ATGAAACAGATTTTAGCAAATTATACAGCGAGCATTACCGAGTTGAAAAAATCACCTACAAAACTGCTGGATGAGGCTGG
TAATGAGCCTATCGCAATTTTGAATCATAATACACCAAGTGCTTATCTTGTGCCCAGCAGTTACTATGAAAAAATAATGG
ACATTCTCGATGAGCATTATTTGGAAAAAGAGGTAAAAGAAGCATTGAACTATAGCAAGGATGAACTCGTAGAGGTTGAT
ATAGATGAGCTTATATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GY41

References