Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1445627..1446246 Replicon chromosome
Accession NZ_CP063874
Organism Klebsiella quasipneumoniae strain S174-1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag IOD26_RS07180 Protein ID WP_002892050.1
Coordinates 1446028..1446246 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag IOD26_RS07175 Protein ID WP_002892066.1
Coordinates 1445627..1446001 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD26_RS07165 1440780..1441973 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IOD26_RS07170 1441996..1445142 + 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit -
IOD26_RS07175 1445627..1446001 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
IOD26_RS07180 1446028..1446246 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
IOD26_RS07185 1446405..1446971 + 567 WP_004204750.1 maltose O-acetyltransferase -
IOD26_RS07190 1446943..1447065 - 123 WP_032426076.1 hypothetical protein -
IOD26_RS07195 1447108..1447578 + 471 WP_004204751.1 YlaC family protein -
IOD26_RS07200 1447547..1449004 - 1458 WP_200983287.1 PLP-dependent aminotransferase family protein -
IOD26_RS07205 1449105..1449803 + 699 WP_004204753.1 GNAT family N-acetyltransferase -
IOD26_RS07210 1449800..1449940 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
IOD26_RS07215 1449940..1450203 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T179120 WP_002892050.1 NZ_CP063874:1446028-1446246 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T179120 NZ_CP084561:1388537-1388839 [Arthrobacter sp. FW305-BF8]
GTGTCCGGCGGGACATACGCGCAAAAGCCCAGGCCCGCGCTCATCATTCAGGATGACCTATTTGCAGCATCCGAGTCGGT
CACCCTACTGCCACTGACGTCCCACCTCACGGACGCCCCATTGCTGAGACTGACGGTTGAACCGGGACAGCTCACCGGCT
TGGAGCGCGTAAGCCAGATCATGGTAGACAAGCTCACAACAGTCCGCCGCTCCAACCTGGGGCAGCGGGTAGGCCGGATA
GATTCCAAGACGATGGTTGCAGTTGAACAATCGCTTGCTGTCTTTCTCGGGCTGGGGCGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT179120 WP_002892066.1 NZ_CP063874:1445627-1446001 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT179120 NZ_CP084561:1388352-1388516 [Arthrobacter sp. FW305-BF8]
ATGCGCGAGCGAGGGTTCCGACAGATTCAACTGTGGGTGCCAGACACAAGGACGGAAAAGTTCAGGTACGAGGCTGAGCG
CCAAGCACTGGCGGTTGCCGACTCTGACCGCGCAGGCGACGACCAGGATTTCATAGAACAGATCTCGGAAGACTGGCCGG
AGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References