Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1445627..1446246 | Replicon | chromosome |
Accession | NZ_CP063874 | ||
Organism | Klebsiella quasipneumoniae strain S174-1 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | IOD26_RS07180 | Protein ID | WP_002892050.1 |
Coordinates | 1446028..1446246 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | IOD26_RS07175 | Protein ID | WP_002892066.1 |
Coordinates | 1445627..1446001 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IOD26_RS07165 | 1440780..1441973 | + | 1194 | WP_004204747.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
IOD26_RS07170 | 1441996..1445142 | + | 3147 | WP_004204748.1 | multidrug efflux RND transporter permease subunit | - |
IOD26_RS07175 | 1445627..1446001 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
IOD26_RS07180 | 1446028..1446246 | + | 219 | WP_002892050.1 | hemolysin expression modulator Hha | Toxin |
IOD26_RS07185 | 1446405..1446971 | + | 567 | WP_004204750.1 | maltose O-acetyltransferase | - |
IOD26_RS07190 | 1446943..1447065 | - | 123 | WP_032426076.1 | hypothetical protein | - |
IOD26_RS07195 | 1447108..1447578 | + | 471 | WP_004204751.1 | YlaC family protein | - |
IOD26_RS07200 | 1447547..1449004 | - | 1458 | WP_200983287.1 | PLP-dependent aminotransferase family protein | - |
IOD26_RS07205 | 1449105..1449803 | + | 699 | WP_004204753.1 | GNAT family N-acetyltransferase | - |
IOD26_RS07210 | 1449800..1449940 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
IOD26_RS07215 | 1449940..1450203 | - | 264 | WP_004204754.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T179120 WP_002892050.1 NZ_CP063874:1446028-1446246 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T179120 NZ_CP084561:1388537-1388839 [Arthrobacter sp. FW305-BF8]
GTGTCCGGCGGGACATACGCGCAAAAGCCCAGGCCCGCGCTCATCATTCAGGATGACCTATTTGCAGCATCCGAGTCGGT
CACCCTACTGCCACTGACGTCCCACCTCACGGACGCCCCATTGCTGAGACTGACGGTTGAACCGGGACAGCTCACCGGCT
TGGAGCGCGTAAGCCAGATCATGGTAGACAAGCTCACAACAGTCCGCCGCTCCAACCTGGGGCAGCGGGTAGGCCGGATA
GATTCCAAGACGATGGTTGCAGTTGAACAATCGCTTGCTGTCTTTCTCGGGCTGGGGCGCTGA
GTGTCCGGCGGGACATACGCGCAAAAGCCCAGGCCCGCGCTCATCATTCAGGATGACCTATTTGCAGCATCCGAGTCGGT
CACCCTACTGCCACTGACGTCCCACCTCACGGACGCCCCATTGCTGAGACTGACGGTTGAACCGGGACAGCTCACCGGCT
TGGAGCGCGTAAGCCAGATCATGGTAGACAAGCTCACAACAGTCCGCCGCTCCAACCTGGGGCAGCGGGTAGGCCGGATA
GATTCCAAGACGATGGTTGCAGTTGAACAATCGCTTGCTGTCTTTCTCGGGCTGGGGCGCTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT179120 WP_002892066.1 NZ_CP063874:1445627-1446001 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT179120 NZ_CP084561:1388352-1388516 [Arthrobacter sp. FW305-BF8]
ATGCGCGAGCGAGGGTTCCGACAGATTCAACTGTGGGTGCCAGACACAAGGACGGAAAAGTTCAGGTACGAGGCTGAGCG
CCAAGCACTGGCGGTTGCCGACTCTGACCGCGCAGGCGACGACCAGGATTTCATAGAACAGATCTCGGAAGACTGGCCGG
AGTGA
ATGCGCGAGCGAGGGTTCCGACAGATTCAACTGTGGGTGCCAGACACAAGGACGGAAAAGTTCAGGTACGAGGCTGAGCG
CCAAGCACTGGCGGTTGCCGACTCTGACCGCGCAGGCGACGACCAGGATTTCATAGAACAGATCTCGGAAGACTGGCCGG
AGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |