Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 142084..142888 Replicon plasmid pS141.1
Accession NZ_CP063872
Organism Klebsiella pneumoniae strain S141

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag IRJ19_RS26990 Protein ID WP_072198182.1
Coordinates 142084..142611 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag IRJ19_RS26995 Protein ID WP_048264996.1
Coordinates 142619..142888 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRJ19_RS26965 137724..138905 + 1182 WP_023345579.1 MFS transporter -
IRJ19_RS26970 139024..139632 - 609 WP_023345578.1 short chain dehydrogenase -
IRJ19_RS26975 139730..140632 + 903 WP_048265000.1 LysR family transcriptional regulator -
IRJ19_RS26980 140944..141641 - 698 Protein_151 IS1 family transposase -
IRJ19_RS26985 141692..142000 - 309 WP_064167953.1 hypothetical protein -
IRJ19_RS26990 142084..142611 - 528 WP_072198182.1 GNAT family N-acetyltransferase Toxin
IRJ19_RS26995 142619..142888 - 270 WP_048264996.1 DUF1778 domain-containing protein Antitoxin
IRJ19_RS27000 143816..144991 + 1176 WP_077258344.1 SAVED domain-containing protein -
IRJ19_RS27005 144988..146235 + 1248 WP_048264960.1 nucleotidyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ybtQ / ybtX / ybtS / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP 1..194302 194302
- flank IS/Tn - - 140944..141447 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(54-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 20078.04 Da        Isoelectric Point: 5.7389

>T179118 WP_072198182.1 NZ_CP063872:c142611-142084 [Klebsiella pneumoniae]
VMQELAIEMINDEFDYDIGEFDCGEETLNTFLKDHLKRQHDGQILKGYVLVTKEQKPKLLGYYTLSGSCFERKMLPSKTQ
QRKIPYQNAPSITLGRLAIDKSIQGQGWGELLVTHAMNVVWDASKAVGIYGLFVEALNDKAKRFYTRLDFIQLVGENSNL
LFYPTKSIEKIFTEE

Download         Length: 528 bp

>T179118 NZ_CP084560:c1415216-1414959 [Arthrobacter sp. FW306-2-2C-D06B]
GTGAACTACAACATCACGGTCCTGCCGGCTGCATTGCGGCAGCTGCGCAAGCTTCCTCCCGAGGGCCGCCGCCGGGTCCA
GGCGGCCATCGAGTTGCTGGCTGAGACACCGCGTCCGCCTGGCGCCAAGAAGCTGGCAGGGCGGCTTGAGTGGCGAGTTC
GAACGAGAGATTATCGAGTGCTCTACCGGATCGACGACGGCCGACTCGTGATAGTCGTCGTTCAGGCCGGTCATCGCCGG
GAAATCTACCGGGAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10148.65 Da        Isoelectric Point: 10.1733

>AT179118 WP_048264996.1 NZ_CP063872:c142888-142619 [Klebsiella pneumoniae]
MSALRKQRIDLRLTDDDKSLIEEAAAMSNQTITQFVVASASERAAEVIEQHRRMVLNEESWNLVMDAIANPAAPNERLKR
AAKRLQKMR

Download         Length: 270 bp

>AT179118 NZ_CP084560:c1415479-1415213 [Arthrobacter sp. FW306-2-2C-D06B]
ATGACCGACATAGCCATCACCGAGGCCCGGAACCACCTCGCAACTATTGTGGACACGGCACACCGCGAGCGCGAACCGGT
ATTCCTCACGCGCCGCGGAATTCGGGTCGCGGCAGTAATTGATTCCGCCGAGCTGGAGCGCCTTCGCGAGGCTGCGGAAG
AACTCGAAGACATCCGAGCAGTCGACCTGGCATGGGAAGAGATGGAACAGACCGGTCAGACGCCGATCCCTTGGGAGGAC
GTCAAGCGCGACCTGGGACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References