Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 127731..128374 Replicon plasmid pS141.1
Accession NZ_CP063872
Organism Klebsiella pneumoniae strain S141

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag IRJ19_RS26925 Protein ID WP_023345587.1
Coordinates 127958..128374 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag IRJ19_RS26920 Protein ID WP_023345588.1
Coordinates 127731..127961 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRJ19_RS26895 123823..124251 - 429 WP_023345594.1 nuclear transport factor 2 family protein -
IRJ19_RS26900 124364..125209 - 846 WP_023345593.1 SDR family oxidoreductase -
IRJ19_RS26905 125312..125707 + 396 WP_023345592.1 helix-turn-helix transcriptional regulator -
IRJ19_RS26910 125819..126403 + 585 WP_023345591.1 TetR/AcrR family transcriptional regulator -
IRJ19_RS26915 126471..127313 + 843 WP_048291887.1 nitroreductase family protein -
IRJ19_RS26920 127731..127961 + 231 WP_023345588.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IRJ19_RS26925 127958..128374 + 417 WP_023345587.1 type II toxin-antitoxin system VapC family toxin Toxin
IRJ19_RS26930 128466..129869 - 1404 WP_023345586.1 glycoside hydrolase family 1 protein -
IRJ19_RS26935 129879..131753 - 1875 WP_048291888.1 beta-glucoside-specific PTS transporter subunit IIABC -
IRJ19_RS26940 132143..132778 - 636 WP_023345584.1 DUF1349 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ybtQ / ybtX / ybtS / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP 1..194302 194302


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15082.55 Da        Isoelectric Point: 7.8644

>T179117 WP_023345587.1 NZ_CP063872:127958-128374 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLMLEDWVN

Download         Length: 417 bp

>T179117 NZ_CP084544:94625-94930 [Klebsiella michiganensis]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAAAGCCGCTACCGTCTGTTCGTCGACGTGCAGAGTGACATTATTGACAC
CCCGGGACGCCGGATGGTGATCCCGCTGGTCAGCGCCCGCCTGCTGTCCGACAAAGTCTCGCGTGAGCTTTATCCGGTGG
TGTCAGTCGGAGGTGACCCTTATCGTCTGATGACCACGGATATGGCCAGTGTGCCGGCCACTGTCATCGGGGAAGAAGTG
GCCGATCTCAGCCACCTGGAGAATGACATCCAGAACGCCATCAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.73 Da        Isoelectric Point: 4.4563

>AT179117 WP_023345588.1 NZ_CP063872:127731-127961 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFAP

Download         Length: 231 bp

>AT179117 NZ_CP084544:94405-94623 [Klebsiella michiganensis]
GTGAAGCAGCGTATTACAGTGACAGTGGACAGCGACAGCTATCAGTTGCTCAAGGCATACGACGTAAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGCGCCGAACGCTGGCAGGAAGAAAACCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATCGAGGCTAACGGATCGTTTGCTGACGAAAACAGGGATTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References