Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 88613..89364 Replicon plasmid pS141.1
Accession NZ_CP063872
Organism Klebsiella pneumoniae strain S141

Toxin (Protein)


Gene name ataT Uniprot ID A0A6P1V716
Locus tag IRJ19_RS26705 Protein ID WP_048978473.1
Coordinates 88882..89364 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A6P1V8A4
Locus tag IRJ19_RS26700 Protein ID WP_048978474.1
Coordinates 88613..88891 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRJ19_RS26680 83620..84504 - 885 WP_004186900.1 hypothetical protein -
IRJ19_RS26685 85722..86204 + 483 WP_004210306.1 hypothetical protein -
IRJ19_RS26690 86448..86762 - 315 WP_023288299.1 hypothetical protein -
IRJ19_RS26695 87769..88305 - 537 WP_048978475.1 hypothetical protein -
IRJ19_RS26700 88613..88891 + 279 WP_048978474.1 DUF1778 domain-containing protein Antitoxin
IRJ19_RS26705 88882..89364 + 483 WP_048978473.1 GNAT family N-acetyltransferase Toxin
IRJ19_RS26710 89402..89806 + 405 WP_117042408.1 DUF2251 domain-containing protein -
IRJ19_RS26715 90571..90930 + 360 Protein_98 AAA family ATPase -
IRJ19_RS26720 90919..91356 + 438 Protein_99 conjugative coupling factor TraD, PFGI-1 class -
IRJ19_RS26725 91368..92027 + 660 WP_048977928.1 TIGR03746 family integrating conjugative element protein -
IRJ19_RS26730 92027..92977 + 951 WP_048977927.1 TIGR03749 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ybtQ / ybtX / ybtS / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP 1..194302 194302


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17763.69 Da        Isoelectric Point: 9.4946

>T179115 WP_048978473.1 NZ_CP063872:88882-89364 [Klebsiella pneumoniae]
MGLRPPEPLTPEHNIAEFCCQDQVLSEWLKKKALKNHRTGISRVFVVCAENTNRVIAYYCLASGSVHRNTVPGAYRRNAP
EALPVIVLGRLAVDAAWARKGLGAALLKDAIYRTEHIAIQVGVRALLVHALNDEVREFYTKFGFEPSIANALTLLFPIKT

Download         Length: 483 bp

>T179115 NZ_CP084542:c5392614-5392225 [Klebsiella michiganensis]
ATGCAAACCAAATCACCCCCCTTCATGCGGGCGGCATCGTCACGTCCGTCTCCCGTGGGCGTCTGGCAGACCCTGCTGAC
CTGCCTGCTGGAACACCACTATGGCCTTACGCTTAACGATACGCCGTTCAGTGATGAACTGGTGATTCAGCAACATATCG
AGGCGGGTATCTCGCTGGCCGATGCCCTGAATTTTATTGTTGAAAAGTATGAACTGGTCCGCACTGACCGGCCAGGCTTC
AGCATCAGGGAGCAGTCTCCGTTTATTACATCCATTGATATCCTCCGGGCCAGAAAGGCAACGGGGCTGATGAACCGTGA
CACGTATAAAGAGGTGACGGCTATTACCAGAGGGCAACATCCGCAGGTCAGTGCTCCAGGCAAGCGATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10694.21 Da        Isoelectric Point: 4.5038

>AT179115 WP_048978474.1 NZ_CP063872:88613-88891 [Klebsiella pneumoniae]
MKPDIREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDNQFNAFVEELDAPMTPERQAR
IDNLMSRKSPWD

Download         Length: 279 bp

>AT179115 NZ_CP084542:c5393029-5392670 [Klebsiella michiganensis]
TTGTCGAAGAAAACCACGATAGCAACGCATGATATCAGCGAATCCTGGTGGGGGCTCAGACGCAGTGTCTCCGCGTGTTT
TGGTGCCCGACTGGTCCAGGAGGGAAACCGCCTGCATTACCTGGCTGACCGCGCGAATTTTAACGGACAGTTCTGCGATG
CGGATTTGCGCCATCTTGACCAGTCTTTCCCGGTATTGATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAAT
CCCCGTCATCAGCACTGCGTCACGCTGTATGCAAAAGGTCTGACCTGCGAGGCCGATACGCTCGGTTCGCATGGCTACGT
TTATATCGCGATTTATCCCACTCCCGTCACCACAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1V716

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V8A4

References