Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 58573..59483 | Replicon | plasmid pS141.1 |
| Accession | NZ_CP063872 | ||
| Organism | Klebsiella pneumoniae strain S141 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | R4YBC5 |
| Locus tag | IRJ19_RS26515 | Protein ID | WP_004144067.1 |
| Coordinates | 58573..59043 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | IRJ19_RS26520 | Protein ID | WP_004026357.1 |
| Coordinates | 59040..59483 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IRJ19_RS26480 | 53884..54150 | - | 267 | WP_003026799.1 | DUF1778 domain-containing protein | - |
| IRJ19_RS26485 | 54283..54711 | - | 429 | WP_004901287.1 | GFA family protein | - |
| IRJ19_RS26490 | 54912..55058 | - | 147 | WP_159193595.1 | IS3 family transposase | - |
| IRJ19_RS26495 | 55080..56200 | + | 1121 | WP_085955508.1 | IS3 family transposase | - |
| IRJ19_RS26500 | 56227..57042 | - | 816 | WP_077258365.1 | IS3 family transposase | - |
| IRJ19_RS26505 | 56997..57506 | - | 510 | WP_004901294.1 | IS3 family transposase | - |
| IRJ19_RS26510 | 58202..58462 | + | 261 | WP_048291871.1 | hypothetical protein | - |
| IRJ19_RS26515 | 58573..59043 | - | 471 | WP_004144067.1 | RES family NAD+ phosphorylase | Toxin |
| IRJ19_RS26520 | 59040..59483 | - | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| IRJ19_RS26525 | 59584..60090 | - | 507 | Protein_60 | DUF4113 domain-containing protein | - |
| IRJ19_RS26530 | 60191..60412 | - | 222 | WP_072060588.1 | DUF2188 domain-containing protein | - |
| IRJ19_RS26535 | 60836..61573 | + | 738 | Protein_62 | DUF1311 domain-containing protein | - |
| IRJ19_RS26540 | 61573..61914 | + | 342 | WP_048291869.1 | hypothetical protein | - |
| IRJ19_RS26545 | 62309..63354 | + | 1046 | Protein_64 | IS3 family transposase | - |
| IRJ19_RS26550 | 63409..63783 | + | 375 | WP_173675457.1 | hypothetical protein | - |
| IRJ19_RS26555 | 63713..63937 | + | 225 | WP_127807699.1 | DUF4113 domain-containing protein | - |
| IRJ19_RS26560 | 64016..64244 | + | 229 | Protein_67 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | ybtQ / ybtX / ybtS / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP | 1..194302 | 194302 | |
| - | flank | IS/Tn | - | - | 62656..63354 | 698 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17573.83 Da Isoelectric Point: 4.5152
>T179114 WP_004144067.1 NZ_CP063872:c59043-58573 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T179114 NZ_CP084542:c5336597-5336310 [Klebsiella michiganensis]
ATGCCAATGGAGTTTGAATGGGATGCGAACAAGGCAAGAAGTAATCTAAGAAAACATGGAATCCGGTTTGAAGAAGCGGT
GCTCGTCTTTGACGATCCCCGGCATCTTTCCCGACAGGATCGTTATGAGAATGGTGAATATCGCTGGCAAACTATCGGTC
TCGTTCATGGGGTCATTGTTATCATGGTTGCGCATTCGGTCCGTTTTGAAAGTGGAACAGAGGTCATTCGTATTATCAGC
GCCCGGAAGGCGGACAGCAAAGAGAGAAATCGTTATGAACATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGCGAACAAGGCAAGAAGTAATCTAAGAAAACATGGAATCCGGTTTGAAGAAGCGGT
GCTCGTCTTTGACGATCCCCGGCATCTTTCCCGACAGGATCGTTATGAGAATGGTGAATATCGCTGGCAAACTATCGGTC
TCGTTCATGGGGTCATTGTTATCATGGTTGCGCATTCGGTCCGTTTTGAAAGTGGAACAGAGGTCATTCGTATTATCAGC
GCCCGGAAGGCGGACAGCAAAGAGAGAAATCGTTATGAACATGGTTAA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT179114 WP_004026357.1 NZ_CP063872:c59483-59040 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT179114 NZ_CP084542:c5336323-5336021 [Klebsiella michiganensis]
ATGAACATGGTTAAACATAAACGTGACAATCCGGATACGCTTACGGCTAAGCGAGACGATGAGCTTAAAGCGCTGGCCAA
CAAAACGGATGATGAAATCGATTATAGCGGTATTCCCGCCACAGACGACGCACAGTGGTCAGATGCCGTACGCGGTAAAT
TTTACCGACCGCTAAAAACTCAGGCTTCTGTCCGTATTGATGCCGATATTATGGAGTGGCTTAAACGTCCCGGGAAAGGT
TATCAAACGCGACTGAATGCGATCTTAAGAGAAGCGATGATTCGCGATCTTAACAAGAAATAG
ATGAACATGGTTAAACATAAACGTGACAATCCGGATACGCTTACGGCTAAGCGAGACGATGAGCTTAAAGCGCTGGCCAA
CAAAACGGATGATGAAATCGATTATAGCGGTATTCCCGCCACAGACGACGCACAGTGGTCAGATGCCGTACGCGGTAAAT
TTTACCGACCGCTAAAAACTCAGGCTTCTGTCCGTATTGATGCCGATATTATGGAGTGGCTTAAACGTCCCGGGAAAGGT
TATCAAACGCGACTGAATGCGATCTTAAGAGAAGCGATGATTCGCGATCTTAACAAGAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A384IED8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |