Detailed information of TA system TA179112

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4995322..4996910
• Replicon: chromosome
• Accession: NZ_CP063871
• Organism: Klebsiella pneumoniae strain S141

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: W8UI36
• Locus tag: IRJ19_RS24305
• Protein ID: WP_002904792.1
• Coordinates: 4995322..4996644 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IRJ19_RS24310
• Protein ID: WP_004176198.1
• Coordinates: 4996644..4996910 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IRJ19_RS24290	4990378..4992879	+	2502	WP_135620641.1	fimbrial biogenesis outer membrane usher protein	-
IRJ19_RS24295	4992867..4993871	+	1005	WP_135620639.1	type 1 fimbrial protein	-
IRJ19_RS24300	4994013..4995305	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
IRJ19_RS24305	4995322..4996644	-	1323	WP_002904792.1	type II toxin-antitoxin system HipA family toxin	Toxin
IRJ19_RS24310	4996644..4996910	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
IRJ19_RS24315	4997176..4997502	-	327	WP_004215084.1	hydroxyisourate hydrolase	-
IRJ19_RS24320	4997499..4997999	-	501	WP_117259391.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
IRJ19_RS24325	4997977..4999356	-	1380	WP_117259390.1	purine permease	-
IRJ19_RS24330	4999702..5000856	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
IRJ19_RS24335	5000837..5001760	-	924	WP_073557774.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49171.46 Da
• Isoelectric Point: 7.5357

>T179112 WP_002904792.1 NZ_CP063871:c4996644-4995322 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T179112 NZ_CP084542:4641230-4641448 [Klebsiella michiganensis]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGTTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCTGCGGCCGATCATCGTCTTGCAGAGC
TGACGATGAATAAACTGTATGACAAGATCCCCCCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT179112 WP_004176198.1 NZ_CP063871:c4996910-4996644 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT179112 NZ_CP084542:4640829-4641203 [Klebsiella michiganensis]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGATCCAACCTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTTGCACTTAATTATAAAATTAAGTACGCAGAGGATAATAAGCTGATTACCCAGATTGACGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGCGCAGATCTGCAGAAATGGCGTAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A0E1CEC8