Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3535636..3536408 Replicon chromosome
Accession NZ_CP063871
Organism Klebsiella pneumoniae strain S141

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag IRJ19_RS17090 Protein ID WP_168432725.1
Coordinates 3535636..3536004 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag IRJ19_RS17095 Protein ID WP_049115328.1
Coordinates 3536049..3536408 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRJ19_RS17070 3531580..3532482 - 903 WP_064351591.1 bacteriophage abortive infection AbiH family protein -
IRJ19_RS17075 3532569..3533486 + 918 WP_004114644.1 hypothetical protein -
IRJ19_RS17080 3534108..3535097 + 990 WP_004114642.1 glycosyltransferase -
IRJ19_RS17085 3535236..3535556 + 321 WP_004114640.1 hypothetical protein -
IRJ19_RS17090 3535636..3536004 - 369 WP_168432725.1 TA system toxin CbtA family protein Toxin
IRJ19_RS17095 3536049..3536408 - 360 WP_049115328.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IRJ19_RS17100 3536431..3536652 - 222 WP_064351565.1 DUF987 domain-containing protein -
IRJ19_RS17105 3536666..3537148 - 483 WP_064351564.1 DNA repair protein RadC -
IRJ19_RS17110 3537145..3537378 - 234 WP_064351563.1 hypothetical protein -
IRJ19_RS17115 3537389..3537868 - 480 WP_064351562.1 antirestriction protein -
IRJ19_RS17120 3537947..3538768 - 822 WP_200116739.1 DUF945 domain-containing protein -
IRJ19_RS17125 3538875..3539087 - 213 WP_032755286.1 hypothetical protein -
IRJ19_RS17130 3539173..3539532 - 360 WP_004136901.1 hypothetical protein -
IRJ19_RS17135 3539587..3540051 - 465 WP_004136903.1 hypothetical protein -
IRJ19_RS17140 3540329..3541186 - 858 WP_025107340.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3526933..3553193 26260


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(7-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13600.58 Da        Isoelectric Point: 10.0015

>T179101 WP_168432725.1 NZ_CP063871:c3536004-3535636 [Klebsiella pneumoniae]
IQSLPPQRAASSRLSSVKIWQKLLEYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGFSV
KEQSPFIGSLDMLRARKATGLMTRKGYKTVTDITGGRFSGGK

Download         Length: 369 bp

>T179101 NZ_CP084532:c4179423-4178932 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13365.43 Da        Isoelectric Point: 7.3727

>AT179101 WP_049115328.1 NZ_CP063871:c3536408-3536049 [Klebsiella pneumoniae]
MQKATRVINHNITEPWWGLRRNITPCFGARLVQEGNHLHYLADRASIAGTFNDADLRHLDQAFPVLMKQMELMLTSNELT
PHIQRCITIHAKGLICEADTLGSCGYLYIVIYPASATTA

Download         Length: 360 bp

>AT179101 NZ_CP084532:c4179713-4179420 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References