Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3142529..3143186 Replicon chromosome
Accession NZ_CP063871
Organism Klebsiella pneumoniae strain S141

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IRJ19_RS15185 Protein ID WP_002916310.1
Coordinates 3142776..3143186 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IRJ19_RS15180 Protein ID WP_002916312.1
Coordinates 3142529..3142795 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRJ19_RS15155 3137685..3139118 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
IRJ19_RS15160 3139237..3139965 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IRJ19_RS15165 3140015..3140326 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
IRJ19_RS15170 3140490..3141149 + 660 WP_002916317.1 hemolysin III family protein -
IRJ19_RS15175 3141300..3142283 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
IRJ19_RS15180 3142529..3142795 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IRJ19_RS15185 3142776..3143186 + 411 WP_002916310.1 protein YgfX Toxin
IRJ19_RS15190 3143193..3143714 - 522 WP_004144730.1 flavodoxin FldB -
IRJ19_RS15195 3143815..3144711 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IRJ19_RS15200 3144734..3145447 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IRJ19_RS15205 3145453..3147186 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179100 WP_002916310.1 NZ_CP063871:3142776-3143186 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179100 NZ_CP084532:c4072320-4072036 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179100 WP_002916312.1 NZ_CP063871:3142529-3142795 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179100 NZ_CP084532:c4072552-4072310 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References