Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1663720..1664530 Replicon chromosome
Accession NZ_CP063871
Organism Klebsiella pneumoniae strain S141

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag IRJ19_RS08025 Protein ID WP_004178461.1
Coordinates 1663720..1664253 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag IRJ19_RS08030 Protein ID WP_200985673.1
Coordinates 1664264..1664530 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRJ19_RS08020 1662551..1663672 + 1122 WP_200985672.1 cupin domain-containing protein -
IRJ19_RS08025 1663720..1664253 - 534 WP_004178461.1 GNAT family N-acetyltransferase Toxin
IRJ19_RS08030 1664264..1664530 - 267 WP_200985673.1 DUF1778 domain-containing protein Antitoxin
IRJ19_RS08035 1664633..1666066 - 1434 WP_200985674.1 Cu(+)/Ag(+) sensor histidine kinase -
IRJ19_RS08040 1666056..1666739 - 684 WP_004214143.1 copper response regulator transcription factor CusR -
IRJ19_RS08045 1666912..1668297 + 1386 WP_200985699.1 efflux transporter outer membrane subunit -
IRJ19_RS08050 1668315..1668659 + 345 WP_200985700.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T179095 WP_004178461.1 NZ_CP063871:c1664253-1663720 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T179095 NZ_CP084532:c2693410-2693307 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT179095 WP_200985673.1 NZ_CP063871:c1664530-1664264 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSLIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT179095 NZ_CP084532:2693305-2693450 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure

References