Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4461836..4462455 Replicon chromosome
Accession NZ_CP063865
Organism Klebsiella pneumoniae strain S130-1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag IOD48_RS21960 Protein ID WP_002892050.1
Coordinates 4461836..4462054 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag IOD48_RS21965 Protein ID WP_002892066.1
Coordinates 4462081..4462455 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD48_RS21925 4457883..4458146 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
IOD48_RS21930 4458146..4458286 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
IOD48_RS21935 4458283..4458981 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
IOD48_RS21940 4459082..4460533 + 1452 WP_021313732.1 PLP-dependent aminotransferase family protein -
IOD48_RS21945 4460508..4460978 - 471 WP_002892026.1 YlaC family protein -
IOD48_RS21950 4460999..4461139 + 141 WP_004147370.1 hypothetical protein -
IOD48_RS21955 4461111..4461677 - 567 WP_002892030.1 maltose O-acetyltransferase -
IOD48_RS21960 4461836..4462054 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
IOD48_RS21965 4462081..4462455 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
IOD48_RS21970 4462941..4466087 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
IOD48_RS21975 4466110..4467303 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T179067 WP_002892050.1 NZ_CP063865:c4462054-4461836 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T179067 NZ_CP084529:2178896-2179237 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT179067 WP_002892066.1 NZ_CP063865:c4462455-4462081 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT179067 NZ_CP084529:c2178901-2178825 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References