179065

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3821244..3821914 Replicon chromosome
Accession NZ_CP063865
Organism Klebsiella pneumoniae strain S130-1

Toxin (Protein)


Gene name ypjF Uniprot ID A0A483GLH7
Locus tag IOD48_RS18865 Protein ID WP_023301398.1
Coordinates 3821582..3821914 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A483GII7
Locus tag IOD48_RS18860 Protein ID WP_023301397.1
Coordinates 3821244..3821561 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD48_RS18815 3816385..3817209 + 825 WP_023301389.1 DUF945 domain-containing protein -
IOD48_RS18820 3817418..3818128 + 711 WP_023301390.1 DeoR family transcriptional regulator -
IOD48_RS18825 3818154..3818690 + 537 WP_023301391.1 DUF4339 domain-containing protein -
IOD48_RS18830 3818732..3819169 + 438 WP_023301392.1 hypothetical protein -
IOD48_RS18835 3819236..3819646 + 411 WP_023301393.1 hypothetical protein -
IOD48_RS18840 3819724..3819960 + 237 WP_032446575.1 DUF905 domain-containing protein -
IOD48_RS18845 3820046..3820504 + 459 WP_023301394.1 antirestriction protein -
IOD48_RS18850 3820513..3820995 + 483 WP_023301395.1 RadC family protein -
IOD48_RS18855 3821004..3821225 + 222 WP_023301396.1 DUF987 domain-containing protein -
IOD48_RS18860 3821244..3821561 + 318 WP_023301397.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IOD48_RS18865 3821582..3821914 + 333 WP_023301398.1 TA system toxin CbtA family protein Toxin
IOD48_RS18870 3822309..3823208 + 900 WP_077253334.1 hypothetical protein -
IOD48_RS18875 3823607..3824718 + 1112 Protein_3685 IS3 family transposase -
IOD48_RS18880 3824735..3824923 + 189 Protein_3686 transposase -
IOD48_RS18885 3825122..3825562 - 441 WP_004146852.1 hypothetical protein -
IOD48_RS18890 3825523..3826005 - 483 WP_194968060.1 hypothetical protein -
IOD48_RS18895 3826016..3826688 - 673 Protein_3689 DUF4400 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-101)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12610.65 Da        Isoelectric Point: 5.6692

>T179065 WP_023301398.1 NZ_CP063865:3821582-3821914 [Klebsiella pneumoniae]
MKTLPATTPQTAKLCLTSADTWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIPLADAVNFLVDKYALVRIDRRGL
SWQEQSSYLRLVDTQRTIKVIELWLFGVMM

Download         Length: 333 bp

>T179065 NZ_CP084529:1618856-1619263 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11785.37 Da        Isoelectric Point: 6.6277

>AT179065 WP_023301397.1 NZ_CP063865:3821244-3821561 [Klebsiella pneumoniae]
MSNITWGLQRDITPCLGSRLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSSGYVYIAVYLTQR

Download         Length: 318 bp

>AT179065 NZ_CP084529:1618609-1618875 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A483GII7

References