Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 604287..605875 Replicon chromosome
Accession NZ_CP063865
Organism Klebsiella pneumoniae strain S130-1

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag IOD48_RS03220 Protein ID WP_004190166.1
Coordinates 604553..605875 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag IOD48_RS03215 Protein ID WP_002904790.1
Coordinates 604287..604553 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD48_RS03190 599438..600361 + 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -
IOD48_RS03195 600342..601496 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
IOD48_RS03200 601842..603221 + 1380 WP_004184021.1 purine permease -
IOD48_RS03205 603199..603699 + 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
IOD48_RS03210 603696..604022 + 327 WP_004143476.1 hydroxyisourate hydrolase -
IOD48_RS03215 604287..604553 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
IOD48_RS03220 604553..605875 + 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
IOD48_RS03225 605892..607184 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
IOD48_RS03230 607326..608330 - 1005 WP_004190163.1 type 1 fimbrial protein -
IOD48_RS03235 608318..610819 - 2502 WP_004190161.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T179049 WP_004190166.1 NZ_CP063865:604553-605875 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T179049 NZ_CP084521:c1090031-1089828 [Edwardsiella ictaluri]
ATGACAAAAATCGATTATCTGATGAAGTTGCGTAAATGCACGACGCTGGATACTCTGGAACGCGTGATCGAAAAGAACAA
ATACGAACTTTCAGATGATGAGCTGGAAATTTTTTATTCTGCCGCAGATCATCGACTGGCTGAATTAACCATGAATAAAC
TATACGACAAAATTCCGGCAGAAGTTTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT179049 WP_002904790.1 NZ_CP063865:604287-604553 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT179049 NZ_CP084521:c1090420-1090052 [Edwardsiella ictaluri]
ATGGATGAGAACACTTCTTATCAGCATGACATCTCAGAGTTAAAATACCTGTGTGATTACCTGTATCATCAGGGAATAGA
TGTCTTGGGAGAAAGCAATCACGGCTGGGTCAGCGATCCGACGGCAGAAGTAAATCTACAGCTTAACGAGCTGATTGAGC
ATATTGCCAGCATCGCGCAATCATTTAAGATCAAATATCCGCGTCATTCGGATTTAGCCGAAATGCTGGATTATTATCTG
GATGAAACCTATGCCCTGTTTGGCACCTATAGCATAAGTGAAACGGCGCTCAGGCAATGGTTGCGTACCAAACGTCGGAT
GGCATACTGTCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References