Detailed information of TA system TA179047

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4176131..4177719
• Replicon: chromosome
• Accession: NZ_CP063863
• Organism: Klebsiella pneumoniae strain M63-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IOD47_RS20120
• Protein ID: WP_032414910.1
• Coordinates: 4176131..4177453 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: IOD47_RS20125
• Protein ID: WP_002904790.1
• Coordinates: 4177453..4177719 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IOD47_RS20105	4171187..4173688	+	2502	WP_032414912.1	fimbrial biogenesis outer membrane usher protein	-
IOD47_RS20110	4173676..4174680	+	1005	WP_004176196.1	type 1 fimbrial protein	-
IOD47_RS20115	4174822..4176114	+	1293	WP_032414911.1	glycoside hydrolase family 10 protein	-
IOD47_RS20120	4176131..4177453	-	1323	WP_032414910.1	type II toxin-antitoxin system HipA family toxin	Toxin
IOD47_RS20125	4177453..4177719	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
IOD47_RS20130	4177985..4178311	-	327	WP_032414908.1	hydroxyisourate hydrolase	-
IOD47_RS20135	4178308..4178808	-	501	WP_032414907.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
IOD47_RS20140	4178786..4180165	-	1380	WP_004184021.1	purine permease	-
IOD47_RS20145	4180511..4181665	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
IOD47_RS20150	4181646..4182569	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49150.45 Da
• Isoelectric Point: 7.5618

>T179047 WP_032414910.1 NZ_CP063863:c4177453-4176131 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGHDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T179047 NZ_CP084514:c3212142-3211486 [Edwardsiella piscicida]
ATGGCTTATGACTACAGCGCCAGTCTCAACCCGCAAAAAGCCCTGATCTGGCGCATTGTCCATCGGGATAATATCCCGTG
GATACTGGACAACGGCTTGCACTGCGGCAACAGTCAAGTGCAGGCGGTAAACTGGATCAATATCGGCAACCCGGAACTTA
TCGGCAAACGCGCCGGGCATCCGGTGCCTGTCGGGACGGGCGGGACGCTGCATGACTACGTGCCGTTTTACTTTACCCCC
TTTTCGCCGATGCTGATGAATATCCACAGCGGGCGTGGCGGCATTACGCAGCGCCCCAACGAGGAAATCGTCATTCTGGT
CAGCAGCCTGCGAAGCGTGGCGGCGCAAAACGCCCCCTTCGTGTTTACCGACAGCCATGCCTACTATAACTGGGCCAACT
ACTACACCCGCCTGGAGGACCTGAACCAGATCGACTGGTCTATCTTACAGGCGCGGGATTTCCGTCGCGATCCGGACGAT
CCGGCGAAGTTTGAACGCTATCAGGCCGAGGCGTTAATCTGGCAGCACTGCCCCATCACACTGCTGGTCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGCTGTCGCAACGTAATCTGACAATGCCCGTTCACGCACGGGCCG
GGTGGTACTTCTCATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT179047 WP_002904790.1 NZ_CP063863:c4177719-4177453 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT179047 NZ_CP084514:c3211450-3210422 [Edwardsiella piscicida]
GTGGAAGCACTGGTGAATACGGTGAATACCGTCGGTGTCATGGGTAAAGGCATCGCGCTGATGTTTAAAGAGCGCTTCCC
CGACAATATGAAAGCCTATGCCCACGCCTGCAAACAAAAGCAGGTGATGACCGGCAAGATGTTTATTACCGAAACCGGCG
AGTTGATGGGGCCGCGCTGGATCGTCAACTTCCCTACCAAGCAGCACTGGCGCGCCGACTCTCGCATGGCGTGGATCGAG
GACGGCTTGCAGGACCTGCGCCGCTTTTTGATCGAAAAGAAAGTGCGGTCCATCGCCATTCCCCCGCTGGGCGCGGGCAA
CGGCGGCCTGAACTGGCCGGACGTCCGGGCGCGGATTGAATCTGCGCTGGGCGACCTTCAGGACACGGAAATCCTGATTT
ATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAGCAGCGGTGTAAAAAAGCTCACTCCCGCCAGAGCGATGATCGCT
GAACTGGTGCGCCGCTACTGGGTGCTGGGCATGGAGTGCAGCCTGCTGGAAATCCAGAAGCTGGCGTGGCTGCTACAACG
CGCCATTGAACTGCACCAGCAGGAGGACGTGCTAAAACTGCGGTTTGAGGCGCACTATTACGGCCCCTATGCTCCTAACC
TGAACCATCTGCTTAACGCGCTGGACGGTACCTATCTGAAAGCCGAAAAGCGTATCCCGGACAGCCAGCCACTGGATGTG
ATCTGGTTTAACGATCGGGAAAAAGAACACATCAACCTATGGCTGAACAGCGAAGCCAAAGCGTGGTTGCCAGCGCTTGA
GCAGGTCAGCCAGTTGATTGACGGTTTTGAATCGCCGTTTGGTCTGGAGCTGTTGGCGACCGTTGACTGGTTGTTGACCC
GGGGACAATGCCAGCCCACGCTGGACTCCGTGAAAGAGGGGTTGCATCAGTGGCCTGCGGGAGAACCTTGGGCCAGCCGT
AAGATAAAGCTGTTTGACGATAAGAATCTGCAATTCGCCATTAACCGCGTGATGGAGTTTCATTGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8