Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2001448..2002105 Replicon chromosome
Accession NZ_CP063858
Organism Klebsiella pneumoniae strain M1026-3Ar

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IOD46_RS09920 Protein ID WP_002916310.1
Coordinates 2001448..2001858 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IOD46_RS09925 Protein ID WP_002916312.1
Coordinates 2001839..2002105 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD46_RS09900 1997448..1999181 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
IOD46_RS09905 1999187..1999900 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IOD46_RS09910 1999923..2000819 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IOD46_RS09915 2000920..2001441 + 522 WP_004144730.1 flavodoxin FldB -
IOD46_RS09920 2001448..2001858 - 411 WP_002916310.1 protein YgfX Toxin
IOD46_RS09925 2001839..2002105 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IOD46_RS09930 2002351..2003334 + 984 WP_064152029.1 tRNA-modifying protein YgfZ -
IOD46_RS09935 2003485..2004144 - 660 WP_002916317.1 hemolysin III family protein -
IOD46_RS09940 2004308..2004619 - 312 WP_064152028.1 N(4)-acetylcytidine aminohydrolase -
IOD46_RS09945 2004669..2005397 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IOD46_RS09950 2005516..2006949 + 1434 WP_064152027.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T179014 WP_002916310.1 NZ_CP063858:c2001858-2001448 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T179014 NZ_CP084497:c4816445-4815912 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT179014 WP_002916312.1 NZ_CP063858:c2002105-2001839 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT179014 NZ_CP084497:c4816722-4816456 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References