Detailed information of TA system TA178999

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3298854..3299370
• Replicon: chromosome
• Accession: NZ_CP063856
• Organism: Klebsiella pneumoniae strain N1059-5At

Toxin (Protein)

• Gene name: relE
• Uniprot ID: J2XDK6
• Locus tag: IOD44_RS15840
• Protein ID: WP_002886902.1
• Coordinates: 3298854..3299138 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: IOD44_RS15845
• Protein ID: WP_002886901.1
• Coordinates: 3299128..3299370 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IOD44_RS15815	3294250..3294558	-	309	WP_101986876.1	PTS sugar transporter subunit IIB	-
IOD44_RS15820	3294643..3294816	+	174	WP_032408826.1	hypothetical protein	-
IOD44_RS15825	3294819..3295562	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
IOD44_RS15830	3295919..3298057	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
IOD44_RS15835	3298386..3298850	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
IOD44_RS15840	3298854..3299138	-	285	WP_002886902.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IOD44_RS15845	3299128..3299370	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IOD44_RS15850	3299448..3301358	-	1911	WP_009486549.1	BglG family transcription antiterminator	-
IOD44_RS15855	3301381..3302535	-	1155	WP_004178372.1	lactonase family protein	-
IOD44_RS15860	3302602..3303342	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11125.95 Da
• Isoelectric Point: 10.3787

>T178999 WP_002886902.1 NZ_CP063856:c3299138-3298854 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T178999 NZ_CP084493:9126-9596 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT178999 WP_002886901.1 NZ_CP063856:c3299370-3299128 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT178999 NZ_CP084493:8686-9129 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Toxin

• AlphaFold DB: A0A0H3GMH2

Antitoxin

• AlphaFold DB: A0A0H3GLP0