Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3231701..3233251 Replicon chromosome
Accession NZ_CP063856
Organism Klebsiella pneumoniae strain N1059-5At

Toxin (Protein)


Gene name hipA Uniprot ID A0A5P2M5J7
Locus tag IOD44_RS15560 Protein ID WP_064188549.1
Coordinates 3231701..3232996 (-) Length 432 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5P2M8A1
Locus tag IOD44_RS15565 Protein ID WP_032724128.1
Coordinates 3233000..3233251 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD44_RS15535 3226759..3228345 + 1587 WP_064188552.1 TraI domain-containing protein -
IOD44_RS15540 3228563..3229171 - 609 WP_064188567.1 hypothetical protein -
IOD44_RS15545 3229164..3230195 - 1032 WP_104456184.1 ParA family protein -
IOD44_RS15550 3230567..3231235 - 669 WP_064188551.1 HNH endonuclease -
IOD44_RS15555 3231347..3231613 - 267 WP_064188550.1 hypothetical protein -
IOD44_RS15560 3231701..3232996 - 1296 WP_064188549.1 type II toxin-antitoxin system HipA family toxin Toxin
IOD44_RS15565 3233000..3233251 - 252 WP_032724128.1 helix-turn-helix domain-containing protein Antitoxin
IOD44_RS15570 3233789..3234898 - 1110 WP_064188548.1 hypothetical protein -
IOD44_RS15575 3235041..3236192 + 1152 WP_142373231.1 hypothetical protein -
IOD44_RS15580 3236345..3236638 + 294 WP_074196054.1 recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3192872..3236638 43766


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-398)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 49221.62 Da        Isoelectric Point: 7.2369

>T178998 WP_064188549.1 NZ_CP063856:c3232996-3231701 [Klebsiella pneumoniae]
VERLTVALNGIIVGTLEKTAGGEMSFYYQRDWLERAGSRAISLSMPLREERYRGEIVYNFFDNLLPDSEQIRSRIQARFH
APTKQPFDLLARIGMDCVGAIQLWPYETDIPSIQRVDAEPLTENEIEHLLQGYKDAPLGMQAEVDDFRISLAGAQEKTAL
LWWNNRWCRPRGSTPTSHIFKLPIGYIANNGIDLRESVENEWLCSKIAAEFGFPVADTRVAYFGQQKILIVERFDRRWAK
DGQWLMRLPTEDFCQALGVAPALKYESDGGPGIARSMDLLLGSQQPLKDRILFFRSQIFFWMLAAIDGHAKNFSVFLEPN
SAYRMAPLYDVMSAYPLMHPKGIPPRKAKMAMALSGRNRHFHWSTIMPRHFLSTAREVSFPVLQVEQLLAEMKQRTESVI
SKVETMLPAGFPEHISEAIFEGLRHQSARIP

Download         Length: 1296 bp

>T178998 NZ_CP084492:c5299775-5299392 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9506.81 Da        Isoelectric Point: 9.9484

>AT178998 WP_032724128.1 NZ_CP063856:c3233251-3233000 [Klebsiella pneumoniae]
MNVTSPKMLAQAVRDARKQRKLTQREAAESMSMKQSTVSEFENHPEGTRLDTLFKLLAALDLELQVVSRKGKNKTSEGWD
QEW

Download         Length: 252 bp

>AT178998 NZ_CP084492:c5300017-5299775 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P2M5J7

Antitoxin

Source ID Structure
AlphaFold DB A0A5P2M8A1

References