Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3437666..3438323 Replicon chromosome
Accession NZ_CP063851
Organism Klebsiella pneumoniae strain M1023-4Ar

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IOD43_RS16530 Protein ID WP_002916310.1
Coordinates 3437913..3438323 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IOD43_RS16525 Protein ID WP_002916312.1
Coordinates 3437666..3437932 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD43_RS16500 3432822..3434255 - 1434 WP_064152027.1 6-phospho-beta-glucosidase -
IOD43_RS16505 3434374..3435102 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IOD43_RS16510 3435152..3435463 + 312 WP_064152028.1 N(4)-acetylcytidine aminohydrolase -
IOD43_RS16515 3435627..3436286 + 660 WP_002916317.1 hemolysin III family protein -
IOD43_RS16520 3436437..3437420 - 984 WP_064152029.1 tRNA-modifying protein YgfZ -
IOD43_RS16525 3437666..3437932 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IOD43_RS16530 3437913..3438323 + 411 WP_002916310.1 protein YgfX Toxin
IOD43_RS16535 3438330..3438851 - 522 WP_004144730.1 flavodoxin FldB -
IOD43_RS16540 3438952..3439848 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IOD43_RS16545 3439871..3440584 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IOD43_RS16550 3440590..3442323 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T178968 WP_002916310.1 NZ_CP063851:3437913-3438323 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T178968 NZ_CP084443:c1807590-1807378 [Staphylococcus lugdunensis]
GTGGAAAAGCGATTAATTTATATTACAAATGTGACTAGTGAAGACGACTTGGAAAACTTACGAACAAGGTTATTAGAGAT
GATTGGTGTTAATGAAGTAGTGATCAATTTTGATGAACGTGCAGTTAATGTTACTTTTGAAACACCAACTAATTTAAATG
CACTTGAAAAAGAAATATATGATGCTGGCTATCATGCTATAGATGATTTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT178968 WP_002916312.1 NZ_CP063851:3437666-3437932 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT178968 NZ_CP084443:c1807896-1807603 [Staphylococcus lugdunensis]
TTGAACGAACAAGATCATGCACATCATTCTAAAATTGTAAAAGCAAATTTAAAATCTAGATTAAATCGTATAGAAGGACA
AGTGCGGGCAATTAATCGCATGGTTGAAGATGATGTTTATTGTGATGATGTGTTAACACAAATAAGAGCAACACGCTCAG
CATTAACGAGTGTAGCAACAAAACTATTAGAGCATCATATGAAAAGTTGTATCATGGATAAAATAAACGATGGGCAGGAA
GTTGAAGCGATGGAGGAATTGCTAGTTACATTTCAAAAAATGCTAAAAGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References