Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2218168..2219849 Replicon chromosome
Accession NZ_CP063851
Organism Klebsiella pneumoniae strain M1023-4Ar

Toxin (Protein)


Gene name mosT Uniprot ID A0A483YLF8
Locus tag IOD43_RS10650 Protein ID WP_019724882.1
Coordinates 2218168..2219085 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag IOD43_RS10655 Protein ID WP_004177809.1
Coordinates 2219091..2219849 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD43_RS10630 2213474..2214994 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
IOD43_RS10635 2214991..2215989 + 999 WP_002885172.1 ribose ABC transporter permease -
IOD43_RS10640 2216020..2216961 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
IOD43_RS10645 2217036..2218043 + 1008 WP_064152101.1 carbohydrate kinase family protein -
IOD43_RS10650 2218168..2219085 - 918 WP_019724882.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
IOD43_RS10655 2219091..2219849 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
IOD43_RS10660 2219935..2220663 - 729 WP_002885152.1 response regulator transcription factor -
IOD43_RS10665 2220936..2223083 + 2148 WP_077625403.1 formate dehydrogenase subunit alpha -
IOD43_RS10670 2223313..2223999 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34653.14 Da        Isoelectric Point: 5.4707

>T178965 WP_019724882.1 NZ_CP063851:c2219085-2218168 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T178965 NZ_CP084440:2629420-2629884 [Staphylococcus lugdunensis]
ATGGGATTGTACGAAGAGATGTTAATAAAACATGATTACATAGAAATTAAAGAAACAGATGTTATGCCCGATAATTTATC
GGGGGTGTGGTTAGATGACTTAATTTTAATCAATAGTAATCTACCTGAAACACGAAAAACCGAAGTCTTATACGAAGAAT
TAGCACATCATAAACTTACATATGGGAATATCTTAGACCAGTCTAAATGGATAAACAGAAAATTTGAAAACTACGCAAGA
CGACATGGGTACGAAGTAGCACTGCCCTTACGTATCATTGTGGAAGCACATCACTACGGCGTAAGTAACTTATATGAACT
AGCAGAATATGTTCAGTTAAGCGAAGAACACGTATTAGAAATATTGGAACATTACAAACAAAAACACGGTATTGGAATTC
ACTACGGCGAATACTCTATTACATTTGAACCGTTGAGGGTTTTTAAGTTGCATCATATTGATTAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT178965 WP_004177809.1 NZ_CP063851:c2219849-2219091 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT178965 NZ_CP084440:2629085-2629408 [Staphylococcus lugdunensis]
ATGAGAACTTCAGCAGAAATAGGTAAGTTAATAAAACAACTACGTAAAAAGAACAATGTAAATTTAACTGATTTTGCAAC
TAAAATAGGTGTTAATAAATCTACTTTGTCAAGATATGAAAATGGTAGTAGAAAAATACCTATGGAAGATATAGCTGAAA
TCGCAAATGCATTGAATGTTACCCCAGAAAGTTTATTATTAAAAAATAAACAACCAGAAACCGAAGTACAACATCGTGCA
GCTCATCTTGAAGGCGAACTAACAGATGATGAATGGCAACGTGTATTAGACTACGCAGATTATATTAAAAGTAAGCGAAA
ATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YLF8

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References