Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2062691..2063207 Replicon chromosome
Accession NZ_CP063851
Organism Klebsiella pneumoniae strain M1023-4Ar

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag IOD43_RS09855 Protein ID WP_004178374.1
Coordinates 2062691..2062975 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IOD43_RS09860 Protein ID WP_002886901.1
Coordinates 2062965..2063207 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD43_RS09830 2058086..2058394 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
IOD43_RS09835 2058479..2058652 + 174 WP_032412860.1 hypothetical protein -
IOD43_RS09840 2058655..2059398 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IOD43_RS09845 2059755..2061893 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
IOD43_RS09850 2062223..2062687 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IOD43_RS09855 2062691..2062975 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IOD43_RS09860 2062965..2063207 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IOD43_RS09865 2063285..2065195 - 1911 WP_004152270.1 BglG family transcription antiterminator -
IOD43_RS09870 2065218..2066372 - 1155 WP_002886900.1 lactonase family protein -
IOD43_RS09875 2066439..2067179 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T178964 WP_004178374.1 NZ_CP063851:c2062975-2062691 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T178964 NZ_CP084440:c2497120-2496908 [Staphylococcus lugdunensis]
GTGGAAAAGCGATTAATTTATATTACAAATGTGACTAGTGAAGACGACTTGGAAAACTTACGAACAAGGTTATTAGAGAT
GATTGGTGTTAATGAAGTAGTGATCAATTTTGATGAACGTGCAGTTAATGTTACTTTTGAAACACCAACTAATTTAAATG
CACTTGAAAAAGAAATATATGATGCTGGCTATCATGCTATAGATGATTTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT178964 WP_002886901.1 NZ_CP063851:c2063207-2062965 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT178964 NZ_CP084440:c2497426-2497133 [Staphylococcus lugdunensis]
TTGAACGAACAAGATCATGCACATCATTCTAAAATTGTAAAAGCAAATTTAAAATCTAGATTAAATCGTATAGAAGGACA
AGTGCGGGCAATTAATCGCATGGTTGAAGATGATGTTTATTGTGATGATGTGTTAACACAAATAAGAGCAACACGCTCAG
CATTAACGAGTGTAGCAACAAAACTATTAGAGCATCATATGAAAAGTTGTATCATGGATAAAATAAACGATGGGCAGGAA
GTTGAAGCGATGGAGGAATTGCTAGTTACATTTCAAAAAATGCTAAAAGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References