Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 6435320..6435867 Replicon chromosome
Accession NZ_CP063849
Organism Paludibaculum fermentans strain P105

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IRI77_RS25365 Protein ID WP_194447789.1
Coordinates 6435511..6435867 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IRI77_RS25360 Protein ID WP_194447788.1
Coordinates 6435320..6435511 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRI77_RS25340 6430472..6432721 + 2250 WP_194447784.1 nitrite/sulfite reductase -
IRI77_RS25345 6432726..6433244 + 519 WP_194447785.1 hypothetical protein -
IRI77_RS25350 6433335..6434285 + 951 WP_194447786.1 pyridoxal-phosphate dependent enzyme -
IRI77_RS25355 6434286..6435287 + 1002 WP_194447787.1 3-dehydro-L-gulonate 2-dehydrogenase -
IRI77_RS25360 6435320..6435511 + 192 WP_194447788.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IRI77_RS25365 6435511..6435867 + 357 WP_194447789.1 PIN domain-containing protein Toxin
IRI77_RS25370 6435948..6436982 - 1035 WP_194447790.1 hypothetical protein -
IRI77_RS25375 6437046..6437639 - 594 WP_194447791.1 hypothetical protein -
IRI77_RS25380 6437663..6438178 - 516 WP_194447792.1 sigma-70 family RNA polymerase sigma factor -
IRI77_RS25385 6438489..6439970 + 1482 WP_194447793.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12702.82 Da        Isoelectric Point: 6.0609

>T178960 WP_194447789.1 NZ_CP063849:6435511-6435867 [Paludibaculum fermentans]
MVLVDTSVWIQHLRAGEPKLSALLADGLVVMHPFVLGELACGNLKDRATILSSLGSLPAAQLATHAEVLWLIEDSKLSGR
GLGWTDVHLLASSLLSPCEFWTLDKRLFAAASELGLTR

Download         Length: 357 bp

>T178960 NZ_CP084437:503505-503828 [Staphylococcus lugdunensis]
ATGAATTGGGAAATTAAAAATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAATCATGG
TTGGCATTTTGAGGAGTTATATCCACATGAACCAAATCATAACTTAAATAAAGATGAATTAATTAGAGAGGGTTTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAACAGTTCGATAAAATTATACAA
AAGTTTCATGAATTAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCACAAAAATTAAAAATCACAGA
GTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 6906.03 Da        Isoelectric Point: 11.6533

>AT178960 WP_194447788.1 NZ_CP063849:6435320-6435511 [Paludibaculum fermentans]
MRTTLIIDDHLLERARELTGIEEKTALVRAGLEALIAREAGRRLAALGGSQPKLASIPRRRSS

Download         Length: 192 bp

>AT178960 NZ_CP084437:503293-503502 [Staphylococcus lugdunensis]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References