Detailed information of TA system TA178959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 5861097..5861647
• Replicon: chromosome
• Accession: NZ_CP063849
• Organism: Paludibaculum fermentans strain P105

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: -
• Locus tag: IRI77_RS23040
• Protein ID: WP_194447357.1
• Coordinates: 5861097..5861387 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: IRI77_RS23045
• Protein ID: WP_194447358.1
• Coordinates: 5861384..5861647 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IRI77_RS23020	5856252..5858690	+	2439	WP_194447353.1	DNA internalization-related competence protein ComEC/Rec2	-
IRI77_RS23025	5858694..5858951	-	258	WP_194447354.1	DUF2007 domain-containing protein	-
IRI77_RS23030	5859081..5859353	+	273	WP_194447355.1	YtxH domain-containing protein	-
IRI77_RS23035	5859359..5860912	+	1554	WP_194447356.1	L-glutamate gamma-semialdehyde dehydrogenase	-
IRI77_RS23040	5861097..5861387	+	291	WP_194447357.1	BrnT family toxin	Toxin
IRI77_RS23045	5861384..5861647	+	264	WP_194447358.1	BrnA antitoxin family protein	Antitoxin
IRI77_RS23050	5861601..5862389	-	789	WP_194447359.1	DUF429 domain-containing protein	-
IRI77_RS23055	5862386..5862997	-	612	WP_194447360.1	MOSC domain-containing protein	-
IRI77_RS23060	5863225..5864085	-	861	WP_194447361.1	carbon-nitrogen hydrolase family protein	-
IRI77_RS23065	5864163..5866103	-	1941	WP_194447362.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (31-78)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10958.50 Da
• Isoelectric Point: 6.8706

>T178959 WP_194447357.1 NZ_CP063849:5861097-5861387 [Paludibaculum fermentans]
VTRYEWDENKNRANKAKHGLSFETAILVFQDPYVLSEVERVVDGEERWQSIGLIAGTLIVLVIHTWHVGGKPGEIIRVIS
ARKATSKEQHCYENLL

Nucleotide

• Length: 291 bp

>T178959 NZ_CP084437:451809-452159 [Staphylococcus lugdunensis]
ATGATTAGACGCGGCGATGTATATTTAGCTGATTTATCACCGGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGT
TATCATTCAAAATGACACCGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCGA
AAATACCCACTCATGTGGAAATAGGTAAAAAGAAATATAAGTTAGATAAAGATTCTGTTATTCTGTTAGAGCAAATACGA
ACATTAGATAAAAAAAGATTAAAAGAAAAACTTACTTATCTCTCTGAGGATAAAATGAAAGAAGTAGATCATGCCCTAGA
CATTAGTCTAGGTTTACATAACTATCATTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9956.59 Da
• Isoelectric Point: 10.4094

>AT178959 WP_194447358.1 NZ_CP063849:5861384-5861647 [Paludibaculum fermentans]
MKKLTLQQKTELEALAGQPDSQIDTSDIPEVSFSDKAVVGKFYRPIKKPVSVRLDADVLDWLKRSGPGYQRRINLILRLE
MQRSLKT

Nucleotide

• Length: 264 bp

>AT178959 NZ_CP084437:451642-451812 [Staphylococcus lugdunensis]
ATGCTAACTTTTAATCAAAATCGTAGTCATAGTCTAGAACAGTCATTAAAAGAAGGGTATGCTCAGATGGCAGACCTTAA
TCTCTCCCTAGCAACAGAGGCTTTTCCAATTGAATGTGAAGCTTGTGATTGCAATGAAACTTATCTAACTTCCAATCATC
AGAGTGAATGA