Detailed information of TA system TA178958

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yafQ-relB/YafQ-RelB
• Location: 3893984..3894511
• Replicon: chromosome
• Accession: NZ_CP063849
• Organism: Paludibaculum fermentans strain P105

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: IRI77_RS15235
• Protein ID: WP_194452898.1
• Coordinates: 3894245..3894511 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IRI77_RS15230
• Protein ID: WP_194453670.1
• Coordinates: 3893984..3894241 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IRI77_RS15220	3889547..3892375	-	2829	WP_194452896.1	insulinase family protein	-
IRI77_RS15225	3892563..3893228	-	666	WP_194452897.1	hypothetical protein	-
IRI77_RS15230	3893984..3894241	+	258	WP_194453670.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IRI77_RS15235	3894245..3894511	+	267	WP_194452898.1	type II toxin-antitoxin system YafQ family toxin	Toxin
IRI77_RS15240	3894646..3897129	-	2484	WP_194452899.1	erythromycin esterase family protein	-
IRI77_RS15245	3897733..3898803	+	1071	WP_194452900.1	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (8-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-84)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10196.78 Da
• Isoelectric Point: 8.9632

>T178958 WP_194452898.1 NZ_CP063849:3894245-3894511 [Paludibaculum fermentans]
VRNPITGAQFGRDVKLARKRGKDMAKLHDVILLLIEGSPLPSRYKDHTLGGEWKHFRDCHIQPDWLLIYKIEGEDLYLVR
TGTHSDLF

Nucleotide

• Length: 267 bp

>T178958 NZ_CP084437:440554-440766 [Staphylococcus lugdunensis]
GTGGAAAAGCGATTAATTTATATTACAAATGTGACTAATGAAGACGACTTGGAAAACTTACGAACAAGGTTATTAGAGAT
GATTGGTGTTAATGAAGTAGTGATCAATTTTGATGAACGTGCAGTTAATGTTACTTTCGAAACATCAACTAATTTAAATG
CACTTGAAAAAGAAATATATGATGCTGGCTATCATGCTATAGATGATTTATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9255.98 Da
• Isoelectric Point: 11.1195

>AT178958 WP_194453670.1 NZ_CP063849:3893984-3894241 [Paludibaculum fermentans]
IMSTTMIHVRVDEKTKQRATKTLAAMGISVSDAVRMLLVRVVAEKALPFEVKVPNATTVKAMRAADKGQGKRQKSGDTLF
KDLGI

Nucleotide

• Length: 258 bp

>AT178958 NZ_CP084437:440248-440541 [Staphylococcus lugdunensis]
TTGAACGAACAAGATCATGCACATCATTCTAAAATTGTAAAAGCAAATTTAAAATCTAGATTAAATCGTATAGAAGGACA
AGTGCGGGCAATTAATCGCATGGTTGAAGATGATGTTTATTGTGATGATGTGTTAACACAAATAAGAGCAACACGCTCAG
CATTAACGAGTGTAGCAACAAAACTATTAGAGCATCATATGAAAAGTTGTATCATGGATAAAATAAACGATGGGCAGGAA
GTTGAAGCGATGGAGGAATTGCTAGTTACATTTCAAAAGATGCTAAAAGACTAG