Detailed information of TA system TA178957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09812-ChpS
• Location: 2727403..2727992
• Replicon: chromosome
• Accession: NZ_CP063849
• Organism: Paludibaculum fermentans strain P105

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: -
• Locus tag: IRI77_RS10600
• Protein ID: WP_194452041.1
• Coordinates: 2727403..2727735 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: IRI77_RS10605
• Protein ID: WP_194452042.1
• Coordinates: 2727735..2727992 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IRI77_RS10595	2724117..2725685	-	1569	WP_194449598.1	group II intron reverse transcriptase/maturase	-
IRI77_RS10600	2727403..2727735	-	333	WP_194452041.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
IRI77_RS10605	2727735..2727992	-	258	WP_194452042.1	antitoxin	Antitoxin
IRI77_RS10610	2728170..2729747	-	1578	WP_194452043.1	OmpA family protein	-
IRI77_RS10615	2730641..2731027	+	387	WP_194452044.1	DUF2089 domain-containing protein	-
IRI77_RS10620	2731024..2731284	+	261	WP_194452045.1	hypothetical protein	-
IRI77_RS10625	2731293..2731556	+	264	WP_194452046.1	hypothetical protein	-
IRI77_RS10630	2731553..2732008	+	456	WP_194452047.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 11775.60 Da
• Isoelectric Point: 10.2932

>T178957 WP_194452041.1 NZ_CP063849:c2727735-2727403 [Paludibaculum fermentans]
MKRGDIWLVGLDPSERHEQKGRRPVLIVSPEAFNRLTKVPVVLPITSGGSFVRTAGFAVSLSGAGTQTTGVVRCDQPRAL
DLGARGGKRLESVPDAIVEEVLARLAPIFD

Nucleotide

• Length: 333 bp

>T178957 NZ_CP084434:c724437-724225 [Staphylococcus lugdunensis]
GTGGAAAAGCGATTAATTTATATTACAAATGTGACTAGTGAAGACGACTTGGAAAACTTACGAACAAGGTTATTAGAGAT
GATTGGTGTTAATGAAGTAGTGATCAATTTTGATGAACGTGCAGTTAATGTTACTTTTGAAACACCAACTAATTTAAATG
CACTTGAAAAAGAAATATATGATGCTGGCTATCATGCTATAGATGATTTATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9185.81 Da
• Isoelectric Point: 10.3774

>AT178957 WP_194452042.1 NZ_CP063849:c2727992-2727735 [Paludibaculum fermentans]
MYTTSLRKVGGSIMLAVPPALLDLLRLRPGVKVGIAVEGGQLVVKPQSRPRYTLDELLAQCDAKAARSKEDREWVRGKAA
GGELI

Nucleotide

• Length: 258 bp

>AT178957 NZ_CP084434:c724743-724450 [Staphylococcus lugdunensis]
TTGAACGAACAAGATCATGCACATCATTCTAAAATTGTAAAAGCAAATTTAAAATCTAGATTAAATCGTATAGAAGGACA
AGTGCGGGCAATTAATCGCATGGTTGAAGATGATGTTTATTGTGATGATGTGTTAACACAAATAAGAGCAACACGCTCAG
CATTAACGAGTGTAGCAACAAAACTATTAGAGCATCATATGAAAAGTTGTATCATGGATAAAATAAACGATGGGCAGGAA
GTTGAAGCGATGGAGGAATTGCTAGTTACATTTCAAAAGATGCTAAAAGACTAG