Detailed information of TA system TA178945

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3913182..3913983
• Replicon: chromosome
• Accession: NZ_CP063843
• Organism: Morganella morganii strain SMM01

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A0E0XS49
• Locus tag: IR188_RS18815
• Protein ID: WP_001094437.1
• Coordinates: 3913606..3913983 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: IR188_RS18810
• Protein ID: WP_143485436.1
• Coordinates: 3913182..3913559 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IR188_RS18785	3910299..3910457	+	159	WP_001323397.1	DUF905 family protein	-
IR188_RS18790	3910612..3911430	+	819	WP_001234653.1	DUF945 domain-containing protein	-
IR188_RS18795	3911770..3912243	+	474	WP_000855059.1	antirestriction protein	-
IR188_RS18800	3912259..3912735	+	477	WP_001186775.1	RadC family protein	-
IR188_RS18805	3912798..3913019	+	222	WP_000692345.1	DUF987 domain-containing protein	-
IR188_RS18810	3913182..3913559	+	378	WP_143485436.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
IR188_RS18815	3913606..3913983	+	378	WP_001094437.1	TA system toxin CbtA family protein	Toxin
IR188_RS18820	3913980..3914468	+	489	WP_000761716.1	hypothetical protein	-
IR188_RS18825	3914488..3914685	+	198	WP_000772032.1	DUF957 domain-containing protein	-
IR188_RS18830	3914770..3915615	+	846	WP_001274561.1	DUF4942 domain-containing protein	-
IR188_RS18835	3915928..3916962	+	1035	WP_101924532.1	virulence RhuM family protein	-
IR188_RS18840	3917059..3917421	-	363	WP_101924531.1	YibL family ribosome-associated protein	-
IR188_RS18845	3917504..3917896	-	393	WP_081119849.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	tet(B) / aac(6')-Ib-cr / blaOXA-1 / ant(3'')-Ia	-	3868738..3924868	56130

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13986.90 Da
• Isoelectric Point: 7.3223

>T178945 WP_001094437.1 NZ_CP063843:3913606-3913983 [Morganella morganii]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T178945 NZ_CP084432:c1676307-1676205 [Edwardsiella tarda]
GGCAAGGCGATCCATGCCTGCATAATGCCAACTTTTAGCGCACGGCTCTCCACAAGAGCCATTCCCCTAGACCTGATACA
GGAATCGTGTCAGGTCTTTTTTT

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13817.60 Da
• Isoelectric Point: 5.4828

>AT178945 WP_143485436.1 NZ_CP063843:3913182-3913559 [Morganella morganii]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLDSCGYAYLAVYPTPAEPAITV

Nucleotide

• Length: 378 bp

>AT178945 NZ_CP084432:1676202-1676307 [Edwardsiella tarda]
GATAAAAAAAGACCTGACACGATTCCTGTATCAGGTCTAGGGGAATGGCTCTTGTGGAGAGCCGTGCGCTAAAAGTTGGC
ATTATGCAGGCATGGATCGCCTTGCC

Structures

Toxin

• AlphaFold DB: A0A0E0XS49