Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3068950..3069576 Replicon chromosome
Accession NZ_CP063843
Organism Morganella morganii strain SMM01

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag IR188_RS14870 Protein ID WP_024474604.1
Coordinates 3069373..3069576 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag IR188_RS14865 Protein ID WP_004236473.1
Coordinates 3068950..3069309 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IR188_RS14855 3063994..3065196 + 1203 WP_101924268.1 efflux RND transporter periplasmic adaptor subunit -
IR188_RS14860 3065211..3068387 + 3177 WP_015422956.1 multidrug efflux RND transporter permease subunit -
IR188_RS14865 3068950..3069309 + 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
IR188_RS14870 3069373..3069576 + 204 WP_024474604.1 hemolysin expression modulator Hha Toxin
IR188_RS14880 3070449..3071312 + 864 WP_004240378.1 acyl-CoA thioesterase II -
IR188_RS14885 3071373..3072662 - 1290 WP_101924349.1 ammonium transporter AmtB -
IR188_RS14890 3072682..3073020 - 339 WP_004236467.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T178944 WP_024474604.1 NZ_CP063843:3069373-3069576 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T178944 NZ_CP084432:c1667276-1666995 [Edwardsiella tarda]
ATGACCTATAAACTGAGCTTTGAAAAACGTGCCCTGAAAGAGTGGAAAAGGCTGGCACCGCCGATTCAAAGCCAGTTGAA
AAAGAAACTGATCGAACGCCTGGAAAACCCGCATGTTCCAGCAGCACGCTTAAGTGGGCGCGCGAACCGTTATAAAATAA
AATTACGCGCTTCCGGTTACCGGCTCGTCTATGAAGTCAACGATAACGAAATCATCCTACTGGTGATCGCTATCGGCAAA
CGGGCCGATAACGAGGTATACCAGACGGCAGACAGCCGTTAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT178944 WP_004236473.1 NZ_CP063843:3068950-3069309 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT178944 NZ_CP084432:c1667517-1667266 [Edwardsiella tarda]
ATGGCATACCAAATTCTCACGACCACCGCCGCCAGCATTACCGATCTGAAACGTAATCCGATGGGCACCATTGCGGAGGG
TGACGGCAATGCCGTAGCAATATTAAACCGCAATGAGCCGGCCTTTTACTGCGTGCCACCGGAACTCTACGCTTACTATC
TGGAACTGGCTGAAGATGCGGCGCTTAATCGTATCGCCGATGAGCGTCTGGAGGACGCTGAGTTTGTCAGCGTAAGTATC
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References