Detailed information of TA system TA178942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 228504..229321
• Replicon: chromosome
• Accession: NZ_CP063843
• Organism: Morganella morganii strain SMM01

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: IR188_RS01060
• Protein ID: WP_015422406.1
• Coordinates: 228815..229321 (+)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: IR188_RS01055
• Protein ID: WP_101924410.1
• Coordinates: 228504..228812 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IR188_RS01030	223811..224017	-	207	WP_004236540.1	4-oxalocrotonate tautomerase family protein	-
IR188_RS01035	224125..225117	-	993	WP_032098000.1	inner membrane protein YhjD	-
IR188_RS01040	225529..225918	-	390	WP_004236536.1	DUF1090 domain-containing protein	-
IR188_RS01045	226108..226950	+	843	WP_036417394.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
IR188_RS01050	227020..228372	+	1353	WP_046024838.1	glutathione-disulfide reductase	-
IR188_RS01055	228504..228812	+	309	WP_101924410.1	DUF1778 domain-containing protein	Antitoxin
IR188_RS01060	228815..229321	+	507	WP_015422406.1	GNAT family N-acetyltransferase	Toxin
IR188_RS01065	229329..229575	-	247	Protein_211	hypothetical protein	-
IR188_RS01070	229572..230093	-	522	WP_015422407.1	isopentenyl-diphosphate Delta-isomerase	-
IR188_RS01075	230221..230523	-	303	WP_004236529.1	ABC transporter substrate-binding protein	-
IR188_RS01080	230733..231848	-	1116	WP_004236528.1	molybdenum cofactor guanylyltransferase MobA	-
IR188_RS01085	232051..232320	+	270	WP_004240741.1	YihD family protein	-
IR188_RS01090	232320..233315	+	996	WP_036417390.1	serine/threonine protein kinase	-
IR188_RS01095	233334..233957	+	624	WP_004236525.1	thiol:disulfide interchange protein DsbA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (21-94)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18565.43 Da
• Isoelectric Point: 9.9508

>T178942 WP_015422406.1 NZ_CP063843:228815-229321 [Morganella morganii]
MNLTAPEPLQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQ
LATGIYSE

Nucleotide

• Length: 507 bp

>T178942 NZ_CP084432:552253-552675 [Edwardsiella tarda]
GTGGCCCCATGGTGCTGTAATGTCCATGTCTCCTGGCGCACCCAGGTGATCGCGTTGTTGGGATATGGTGCGCTGGTGTT
GACGATCCTCCTGGCCCCCTGGCCTGAGAGTTATGGCGTCAGCGCTTTCTGGTTGCTGCTATTGGTGGTGGTGATCTTCG
AGTGTATCCGTAGCCAGCGCCGTATCGCGCGTAATCGCGGGGAGTTGCAATACAGCGCTACGGGAGAGTGGCGTTGGCAA
CAGCGTGAGTGGCGGCTTGCCCGCCGGCCGTGGATCAGCGATATGGGCGTATTGTTATTGCTACAAAGCAGCGCCGGGCC
GGCACGTCGACGCCGCCTGTGGTTGGCGGCAGACAGTATGAGCCAGGAGGAGTGGAGTGAGTTACGGGCCCTGTTACTGA
ACGCTCCCGAGACCAACGACTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11529.17 Da
• Isoelectric Point: 8.6397

>AT178942 WP_101924410.1 NZ_CP063843:228504-228812 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLETARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Nucleotide

• Length: 309 bp

>AT178942 NZ_CP084432:552006-552272 [Edwardsiella tarda]
ATGGATATCAATAATAAAGCACGGGTTCACTGGGCATGCCGCCGCGGAATGCGTGAGCTGGACATCGCCATTATGCCCTT
CTTCGAGCATGAGTATGATGCGATGAGTGACGCCGATAAGCAGACGTTTGTCCGCCTGCTGAACTGTGATGATCCCGAGC
TGTTCAAGTGGCTGATGAACCAAGGCGTGCCGGAGGATGCCGATCTGGCACGGATGATTACCCTGATTCAGACGCGAAAT
AAAGCACGTGGCCCCATGGTGCTGTAA