Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3714350..3714924 Replicon chromosome
Accession NZ_CP063839
Organism Sphingopyxis granuli strain RW412

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag ICN83_RS17270 Protein ID WP_212597560.1
Coordinates 3714631..3714924 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag ICN83_RS17265 Protein ID WP_076074348.1
Coordinates 3714350..3714634 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICN83_RS17245 (ICN83_17270) 3709835..3710836 - 1002 WP_076077624.1 beta-eliminating lyase-related protein -
ICN83_RS17250 (ICN83_17275) 3710886..3711104 - 219 WP_067113206.1 hypothetical protein -
ICN83_RS17255 (ICN83_17280) 3711297..3712514 - 1218 WP_212597558.1 argininosuccinate synthase -
ICN83_RS17260 (ICN83_17285) 3712963..3714201 - 1239 WP_212597559.1 mechanosensitive ion channel -
ICN83_RS17265 (ICN83_17290) 3714350..3714634 - 285 WP_076074348.1 putative addiction module antidote protein Antitoxin
ICN83_RS17270 (ICN83_17295) 3714631..3714924 - 294 WP_212597560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ICN83_RS17275 (ICN83_17300) 3714967..3716208 - 1242 WP_212597561.1 cyclopropane-fatty-acyl-phospholipid synthase family protein -
ICN83_RS17280 (ICN83_17305) 3716576..3718282 - 1707 WP_212597562.1 class I adenylate-forming enzyme family protein -
ICN83_RS17285 (ICN83_17310) 3718359..3719234 + 876 WP_067110247.1 prolipoprotein diacylglyceryl transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-90)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10732.41 Da        Isoelectric Point: 10.6041

>T178940 WP_212597560.1 NZ_CP063839:c3714924-3714631 [Sphingopyxis granuli]
MIEIRRTDDFIQWIAGLRDVAARARIAKRLNRLAMGNSGDVKSVGGGVSELRFTFGPGYRVYFTRRGDVVVILLCGGDKG
SQSRDIEKAKAMAKEIE

Download         Length: 294 bp

>T178940 NZ_CP084430:c3217223-3216807 [Edwardsiella piscicida]
GTGGTCCTTTGGCGCTGTAATGTTCACGTCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCACGGCACGCTGGTACT
GGCGATCCTGCTGGCGCCCTGGCCGGAAAACTACAGCGTATTCTGGCTGATTCTGCTGGTGGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGCCGGATTGCGCGTAACCGCGGTGAGCTGCAGCTGCTGGCGCCGCAGGTGTGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGACGTCCTTGGGTTAGCGATCTGGGGGCGCTGCTGATCCTGCAGAGTACCCATGGTGCGCCGTG
CCGCCGCCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGCGAAGAGTGGGGGCAGCTGCGCCGCACGCTGCTCGATGCGG
GCGACGATCGCGCATAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10393.94 Da        Isoelectric Point: 4.6437

>AT178940 WP_076074348.1 NZ_CP063839:c3714634-3714350 [Sphingopyxis granuli]
MMAIETKIWDPAELLRTPEDIAAYLDTYLEDGDSEEIREALRTIARSQGMTALARKTGLTREALYKALGENGNPTLDTLV
RICRALGLRLSLAA

Download         Length: 285 bp

>AT178940 NZ_CP084430:c3217470-3217204 [Edwardsiella piscicida]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGCGAGCTGGATATCGCCATCATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGCCTGCTGGCCTGTGACGATCCTGAGC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGATGACGCTGATCTGGCCCGCATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGTCCTTTGGCGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References