Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 829889..830360 Replicon chromosome
Accession NZ_CP063839
Organism Sphingopyxis granuli strain RW412

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ICN83_RS03820 Protein ID WP_076077237.1
Coordinates 829889..830158 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A2L0VTB6
Locus tag ICN83_RS03825 Protein ID WP_067111430.1
Coordinates 830142..830360 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICN83_RS03805 (ICN83_03810) 826315..827340 - 1026 WP_212598255.1 MipA/OmpV family protein -
ICN83_RS03810 (ICN83_03815) 827632..827880 + 249 WP_212598256.1 hypothetical protein -
ICN83_RS03815 (ICN83_03820) 827942..829870 + 1929 WP_212598257.1 1-deoxy-D-xylulose-5-phosphate synthase -
ICN83_RS03820 (ICN83_03825) 829889..830158 - 270 WP_076077237.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ICN83_RS03825 (ICN83_03830) 830142..830360 - 219 WP_067111430.1 DUF6290 family protein Antitoxin
ICN83_RS03830 (ICN83_03835) 830432..830851 - 420 WP_067111427.1 DUF3035 domain-containing protein -
ICN83_RS03835 (ICN83_03840) 830879..831412 - 534 WP_212598258.1 signal peptidase II -
ICN83_RS03840 (ICN83_03845) 831409..834426 - 3018 WP_212598259.1 isoleucine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

Protein of unknown function DUF6290

(3-68)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10306.01 Da        Isoelectric Point: 11.5446

>T178937 WP_076077237.1 NZ_CP063839:c830158-829889 [Sphingopyxis granuli]
MAWTLEFDAAARRQLRKLPRSAGERILAGLEQVAALENPRQRGKALVGERTGYWRYRIGDYRVIAKIEDGRMVILVVAIG
HRREIYRRA

Download         Length: 270 bp

>T178937 NZ_CP084430:1675416-1675504 [Edwardsiella piscicida]
GCAAGGCACTCAATGCCTGCATAATGCCAACTTTTAGCGCACGGCTCTCCAAAAGAGCCATTCCCCTAGACCTGACACAG
GAATCGTGT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8080.22 Da        Isoelectric Point: 4.5348

>AT178937 WP_067111430.1 NZ_CP063839:c830360-830142 [Sphingopyxis granuli]
MLAIRLDKELEERLAAAARRSGRTKTALARKAIEEYIEDLEDIALLEEALNQPDAGKTVSIEQMRRELGLDA

Download         Length: 219 bp

>AT178937 NZ_CP084430:c1675504-1675409 [Edwardsiella piscicida]
ACACGATTCCTGTGTCAGGTCTAGGGGAATGGCTCTTTTGGAGAGCCGTGCGCTAAAAGTTGGCATTATGCAGGCATTGA
GTGCCTTGCTCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2L0VTB6

References