Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2247..2721 Replicon plasmid pCRKP66R-6
Accession NZ_CP063838
Organism Klebsiella pneumoniae strain CRKP66R

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag IRT47_RS29150 Protein ID WP_004197762.1
Coordinates 2247..2513 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag IRT47_RS29155 Protein ID WP_000879771.1
Coordinates 2497..2721 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRT47_RS29135 811..1190 + 380 Protein_0 hypothetical protein -
IRT47_RS29140 1216..1761 + 546 WP_023317533.1 hypothetical protein -
IRT47_RS29145 1827..2177 + 351 WP_004197756.1 hypothetical protein -
IRT47_RS29150 2247..2513 - 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IRT47_RS29155 2497..2721 - 225 WP_000879771.1 TraY domain-containing protein Antitoxin
IRT47_RS29160 3388..3600 - 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
IRT47_RS29165 3607..4116 - 510 WP_032433972.1 MbeB family mobilization protein -
IRT47_RS29170 4091..4855 - 765 Protein_7 relaxase/mobilization nuclease domain-containing protein -
IRT47_RS29175 4794..5138 - 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
IRT47_RS29180 5128..5304 - 177 WP_004197757.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T178935 WP_004197762.1 NZ_CP063838:c2513-2247 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

>T178935 NZ_CP084429:c3271051-3270395 [Edwardsiella piscicida]
ATGGCTTATGACTACAGCGCCAGTCTCAACCCGCAAAAAGCCCTGATCTGGCGCATTGTCCATCGGGATAATATCCCGTG
GATACTGGACAACGGCTTGCACTGCGGCAACAGTCAAGTGCAGGCGGTAAACTGGATCAATATCGGCAACCCGGAACTTA
TCGGCAAACGCGCCGGGCATCCGGTGCCTGTCGGGACGGGCGGGACGCTGCATGACTACGTGCCGTTTTACTTTACCCCC
TTTTCGCCGATGCTGATGAATATCCACAGCGGGCGTGGCGGCATTACGCAGCGCCCCAACGAGGAAATCGTCATTCTGGT
CAGCAGCCTGCGAAGCGTGGCGGCGCAAAACGCCCCCTTCGTGTTTACCGACAGCCATGCCTACTATAACTGGGCCAACT
ACTACACCCGCCTGGAGGACCTGAACCAGATCGACTGGTCTATCTTACAGGCGCGGGATTTCCGTCGCGATCCGGACGAT
CCGGCGAAGTTTGAACGCTATCAGGCCGAGGCGTTAATCTGGCAGCACTGCCCCATCACACTGCTGGTCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGCTGTCGCAACGTAATCTGACAATGCCCGTTCACGCACGGGCCG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT178935 WP_000879771.1 NZ_CP063838:c2721-2497 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp

>AT178935 NZ_CP084429:c3270359-3269331 [Edwardsiella piscicida]
GTGGAAGCACTGGTGAATACGGTGAATACCGTCGGTGTCATGGGTAAAGGCATCGCGCTGATGTTTAAAGAGCGCTTCCC
CGACAATATGAAAGCCTATGCCCACGCCTGCAAACAAAAGCAGGTGATGACCGGCAAGATGTTTATTACCGAAACCGGCG
AGTTGATGGGGCCGCGCTGGATCGTCAACTTCCCTACCAAGCAGCACTGGCGCGCCGACTCTCGCATGGCGTGGATCGAG
GACGGCTTGCAGGACCTGCGCCGCTTTTTGATCGAAAAGAAAGTGCGGTCCATCGCCATTCCCCCGCTGGGCGCGGGCAA
CGGCGGCCTGAACTGGCCGGACGTCCGGGCGCGGATTGAATCTGCGCTGGGCGACCTTCAGGACACGGAAATCCTGATTT
ATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAGCAGCGGTGTAAAAAAGCTCACTCCCGCCAGAGCGATGATCGCT
GAACTGGTGCGCCGCTACTGGGTGCTGGGCATGGAGTGCAGCCTGCTGGAAATCCAGAAGCTGGCGTGGCTGCTACAACG
CGCCATTGAACTGCACCAGCAGGAGGACGTGCTAAAACTGCGGTTTGAGGCGCACTATTACGGCCCCTATGCTCCTAACC
TGAACCATCTGCTTAACGCGCTGGACGGTACCTATCTGAAAGCCGAAAAGCGTATCCCGGACAGCCAGCCACTGGATGTG
ATCTGGTTTAACGATCGGGAAAAAGAACACATCAACCTATGGCTGAACAGCGAAGCCAAAGCGTGGTTGCCAGCGCTTGA
GCAGGTCAGCCAGTTGATTGACGGTTTTGAATCGCCGTTTGGTCTGGAGCTGTTGGCGACCGTTGACTGGTTGTTGACCC
GGGGACAATGCCAGCCCACGCTGGACTCCGTGAAAGAGGGGTTGCATCAGTGGCCTGCGGGAGAACCTTGGGCCAGCCGT
AAGATAAAGCTGTTTGACGATAAGAATCTGCAATTCGCCATTAACCGCGTGATGGAGTTTCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References