Detailed information of TA system TA178923

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4987006..4988687
• Replicon: chromosome
• Accession: NZ_CP063833
• Organism: Klebsiella pneumoniae strain CRKP66R

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: IRT47_RS24660
• Protein ID: WP_002885155.1
• Coordinates: 4987006..4987923 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: W8UPQ8
• Locus tag: IRT47_RS24665
• Protein ID: WP_004151732.1
• Coordinates: 4987929..4988687 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IRT47_RS24640	4982312..4983832	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
IRT47_RS24645	4983829..4984827	+	999	WP_002885172.1	ribose ABC transporter permease	-
IRT47_RS24650	4984858..4985799	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
IRT47_RS24655	4985874..4986881	+	1008	WP_004151731.1	carbohydrate kinase family protein	-
IRT47_RS24660	4987006..4987923	-	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
IRT47_RS24665	4987929..4988687	-	759	WP_004151732.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
IRT47_RS24670	4988773..4989501	-	729	WP_002885152.1	response regulator transcription factor	-
IRT47_RS24675	4989774..4991921	+	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
IRT47_RS24680	4992151..4992837	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T178923 WP_002885155.1 NZ_CP063833:c4987923-4987006 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T178923 NZ_CP084424:c3182999-3182583 [Edwardsiella piscicida]
GTGGTCCTTTGGCGCTGTAATGTTCACGTCTCCTGGCGTACCCAGGTGATGTTTCTGCTGGGGCACGGCACGCTGGTACT
GGCGATCCTGCTGGCGCCCTGGCCGGAAAACTACAGCGTATTCTGGCTGATTCTGCTGGTGGCGGTGATCTTTGAGTGTA
TCCGCAGCCAGCGCCGGATTGCGCGTAACCGCGGTGAGCTGCAGCTGCTGGCGCCGCAGGTGTGGCACTGGCAGCTGCGC
GAGTGGCGCCTGGCCCGACGTCCTTGGGTTAGCGATCTGGGGGCGCTGCTGATCCTGCAGAGTACCCATGGTGCGCCGTG
CCGCCGCCGTCTGTGGCTGGCGGCCGACAGCATGAGCCGCGAAGAGTGGGGGCAGCTGCGCCGCACGCTGCTCGATGCGG
GCGACGATCGCGCATAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28564.92 Da
• Isoelectric Point: 10.0870

>AT178923 WP_004151732.1 NZ_CP063833:c4988687-4987929 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT178923 NZ_CP084424:c3183246-3182980 [Edwardsiella piscicida]
ATGGATATCAATAATAAAGCGCGGGTTCACTGGGCGTGCCGCCGCGGAATGCGCGAGCTGGATATCGCCATCATGCCTTT
CTTTGAACATGAGTATGATGCGCTTAACGATGCCGATAAACAGACCTTTGTCCGCCTGCTGGCCTGTGACGATCCTGAGC
TATTTAAATGGCTGATGAACCAGGGTAAGCCGGATGACGCCGATCTGGCCCGCATGATTACGCTGATTCAGACGCGAAAT
AAAGAACGTGGTCCTTTGGCGCTGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3GH11

Antitoxin

• AlphaFold DB: A0A0H3GQB5