Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4112753..4113372 Replicon chromosome
Accession NZ_CP063833
Organism Klebsiella pneumoniae strain CRKP66R

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag IRT47_RS20430 Protein ID WP_002892050.1
Coordinates 4113154..4113372 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag IRT47_RS20425 Protein ID WP_002892066.1
Coordinates 4112753..4113127 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRT47_RS20415 4107905..4109098 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IRT47_RS20420 4109121..4112267 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
IRT47_RS20425 4112753..4113127 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
IRT47_RS20430 4113154..4113372 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
IRT47_RS20435 4113531..4114097 + 567 WP_002892030.1 maltose O-acetyltransferase -
IRT47_RS20440 4114069..4114209 - 141 WP_004147370.1 hypothetical protein -
IRT47_RS20445 4114230..4114700 + 471 WP_002892026.1 YlaC family protein -
IRT47_RS20450 4114675..4116126 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
IRT47_RS20455 4116227..4116925 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
IRT47_RS20460 4116922..4117062 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
IRT47_RS20465 4117062..4117325 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T178920 WP_002892050.1 NZ_CP063833:4113154-4113372 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T178920 NZ_CP084417:61239-61589 [Klebsiella michiganensis]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT178920 WP_002892066.1 NZ_CP063833:4112753-4113127 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT178920 NZ_CP084417:61594-61896 [Klebsiella michiganensis]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References