Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5100699..5101345 Replicon chromosome
Accession NZ_CP063832
Organism Pseudomonas entomophila strain 23S

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IM733_RS22670 Protein ID WP_248918555.1
Coordinates 5100699..5100881 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IM733_RS22675 Protein ID WP_248918556.1
Coordinates 5100938..5101345 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM733_RS22645 5095709..5096332 - 624 WP_248918550.1 lysophospholipid acyltransferase family protein -
IM733_RS22650 5096343..5096762 - 420 WP_248918551.1 hypothetical protein -
IM733_RS22655 5096759..5098093 - 1335 WP_248918552.1 phosphatase PAP2/dual specificity phosphatase family protein -
IM733_RS22660 5098093..5099847 - 1755 WP_248918553.1 bifunctional alpha/beta hydrolase/class I SAM-dependent methyltransferase -
IM733_RS22665 5099879..5100484 - 606 WP_248918554.1 CDP-alcohol phosphatidyltransferase family protein -
IM733_RS22670 5100699..5100881 + 183 WP_248918555.1 type II toxin-antitoxin system HicA family toxin Toxin
IM733_RS22675 5100938..5101345 + 408 WP_248918556.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IM733_RS22680 5101386..5101700 - 315 WP_248918557.1 putative quinol monooxygenase -
IM733_RS22685 5101900..5102487 + 588 WP_248918558.1 NAD(P)H-dependent oxidoreductase -
IM733_RS22690 5102662..5103558 + 897 WP_248918559.1 LysR family transcriptional regulator -
IM733_RS22695 5103678..5105345 + 1668 WP_248918560.1 gamma-glutamyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6968.03 Da        Isoelectric Point: 11.2510

>T178906 WP_248918555.1 NZ_CP063832:5100699-5100881 [Pseudomonas entomophila]
MRSRDVIQLIEADGWYEVEVKGSHHQFRHPFKRGRVTVPHPKRDLPRGTAHSILKQAGLK

Download         Length: 183 bp

>T178906 NZ_CP084413:c1394438-1394142 [Pseudomonas sp. HS-18]
ATGGCCATTGAACTGAGCGACTTCGACACTAGCCACCACCTCGACAATGAGGAGGTCATTGCCGAATACCTGTCCCAGGT
CCTGTCTGACGGCGATACCGATGAGCTGCTACTCGCCATCGGCAACATTGCCAAGGCGCGCGGCATGACCAAGATCGCCA
ATGACTCGGGACTGGGCCGGGAGAGCCTGTACAAGGTCTTTGCGCCCGGAGCCAAGCCGCGCTTCGAGACGGTCATGAAG
GTCATGCGCGCGCTGGGTGTCGAGTTGCAGGCAATTCCCGCCAGCAGCGGGAAATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14542.39 Da        Isoelectric Point: 4.7269

>AT178906 WP_248918556.1 NZ_CP063832:5100938-5101345 [Pseudomonas entomophila]
MKFPVVLHKDEGSDYGVIVPDVPGCFSAGASVSQALDNVQEALALHFEGLVADGEALPQAQEVDVHVANPDYAGGVWAVV
EFDVTPYLGKAVRFNATLPENLLQRIDEKVKRDHRYASRSGFLASAALRELAVAH

Download         Length: 408 bp

>AT178906 NZ_CP084413:c1394731-1394423 [Pseudomonas sp. HS-18]
ATGACCTATCAGCTAAAGCAAACTGCCCAGTTTGATCACTGGCTTTCTGAGCTCCGCGCCCCCCGCGGGAAAGTCGCAAT
CCTGCGTCGGCTGGACCGTATCCGGTCCGGTCATTTCGGCGACATCCGCTCGGTGGACATCGGTGTCTCGGAAATCCGAC
TGGATGTCGGCCCTGGCTATCGCGTCTACTTCACGCGCCGTGGCGACGTGCCGATCCTGTTGCTGTGTGGCGGCGACAAA
ACATCCCAGCAGCGCGATATCAAGCTGGCGCAGCAACTGGCGGGAGCAATTGAATGGCCATTGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References