Detailed information of TA system TA178905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4072867..4073483
• Replicon: chromosome
• Accession: NZ_CP063832
• Organism: Pseudomonas entomophila strain 23S

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: IM733_RS18025
• Protein ID: WP_110992223.1
• Coordinates: 4073292..4073483 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IM733_RS18020
• Protein ID: WP_248917873.1
• Coordinates: 4072867..4073274 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM733_RS18000	4070109..4070330	-	222	WP_248917869.1	hypothetical protein	-
IM733_RS18005	4070535..4071677	+	1143	WP_248917870.1	copper-containing nitrite reductase	-
IM733_RS18010	4071756..4071965	+	210	WP_248917871.1	DUF3079 domain-containing protein	-
IM733_RS18015	4072024..4072845	+	822	WP_248917872.1	suppressor of fused domain protein	-
IM733_RS18020	4072867..4073274	-	408	WP_248917873.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IM733_RS18025	4073292..4073483	-	192	WP_110992223.1	type II toxin-antitoxin system HicA family toxin	Toxin
IM733_RS18030	4073734..4074603	-	870	WP_248917874.1	LysR family transcriptional regulator	-
IM733_RS18035	4074616..4076862	-	2247	WP_248917875.1	heavy metal translocating P-type ATPase	-
IM733_RS18040	4077052..4077495	+	444	WP_011536217.1	cadmium resistance transcriptional regulator CadR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4064192..4078591	14399

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7039.14 Da
• Isoelectric Point: 10.7339

>T178905 WP_110992223.1 NZ_CP063832:c4073483-4073292 [Pseudomonas entomophila]
INSREMISVIEADGWYLVRSKGSHHHFKHPHKTGLVTIPHPKKDLLPATAASILRQARIGYAS

Nucleotide

• Length: 192 bp

>T178905 NZ_CP084413:c1355092-1354658 [Pseudomonas sp. HS-18]
GTGGCCACGCCCGTCACCTATATGCTGGATACCAACATCTGCTCCTTCATCATGCGCCAGAACCCACCCCAGGTTTTGCA
GCGTCTGCAAAAGGCCGCGGAGTCCGGCAACAGGCTGGTGATTTCGGCTATCACTCATGCGGAGCTTCGTTACGGCGCAG
CGTCACCGAAAGCCCCGAAGGCGGTGGCAGCATGGATCGACGCATTGGTGCAACGCCTGGACGATGTGCTGCCCTGGGAT
ATCGACGCGGTGGATAGCTCCGCGAAGCTCATGAGTCTCCTGCTCGACTCAGGAACGCCCATTGGGCCGAACGATACGGG
CATTGCCAGCCATGCCTTGGCAACCGATTGCGTCATCGTGACCAACAACACCCGCGAATTTCGGCGAGTACCGGGGCTTG
TCGTCGAAGACTGGTGCAACAGCGAACCGGCCTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14697.74 Da
• Isoelectric Point: 4.9080

>AT178905 WP_248917873.1 NZ_CP063832:c4073274-4072867 [Pseudomonas entomophila]
MLFPIAILPGDHQHAWGVEVPDIPGCFSAGDDLDDAIAMAREAIEGHLELLAQDQQEIPKAGKVSEHAANPAYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDSYVQNHPEHKSRSGFLAEAALKVLQGK

Nucleotide

• Length: 408 bp

>AT178905 NZ_CP084413:c1355369-1355097 [Pseudomonas sp. HS-18]
ATGCTCTCTGATCTGGAGGCGCCCACGCCCACGACGACCGTTTCCTTGTTCCGCAACGGCAAGAATCAGGCAGTCCGAAT
CCCTCGGGATATGGAATTCAAGGGAGTGACGGAACTGGTGATGACTCGCGAAGGCGATACGCTCATCCTGCGCCCGTCGC
GGCCCACCTGGAGCAGCCTCGCCGAGCTGGAACCTGTCGATGCCGATTTTCTGGGAGATCGGCCCGACGTGATTGCCCCC
AGCCGGTTGGGCTTCGGCGATGACGAGGGTTGA