178903

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1608375..1609043 Replicon chromosome
Accession NZ_CP063829
Organism Streptococcus pneumoniae strain 19A-ST320_99-176

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag IRE31_RS08140 Protein ID WP_001132282.1
Coordinates 1608864..1609043 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag IRE31_RS08135 Protein ID WP_000961810.1
Coordinates 1608375..1608827 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRE31_RS08115 (IRE31_08080) 1605224..1606258 - 1035 WP_000747915.1 ATP-binding protein -
IRE31_RS08120 (IRE31_08085) 1606392..1606526 - 135 Protein_1606 7,8-dihydro-8-oxoguanine-triphosphatase -
IRE31_RS08125 (IRE31_08090) 1606507..1607595 - 1089 WP_000719711.1 site-2 protease family protein -
IRE31_RS08130 (IRE31_08095) 1607614..1608084 - 471 WP_000257114.1 DUF3013 family protein -
IRE31_RS08135 (IRE31_08100) 1608375..1608827 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IRE31_RS08140 (IRE31_08105) 1608864..1609043 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
IRE31_RS08145 (IRE31_08110) 1609180..1609359 - 180 WP_001048906.1 hypothetical protein -
IRE31_RS08150 (IRE31_08115) 1609524..1609763 - 240 WP_000818079.1 hypothetical protein -
IRE31_RS08155 (IRE31_08120) 1610033..1611304 + 1272 WP_001113206.1 replication-associated recombination protein A -
IRE31_RS08165 (IRE31_08130) 1611851..1613170 - 1320 WP_000502563.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T178903 WP_001132282.1 NZ_CP063829:c1609043-1608864 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T178903 NZ_CP084408:114192-114473 [Sphingobium sp. CFD-2]
ATGCGGACGATTGAACGCTTCGGGCGGTTCAAGCGCGACTACAAGCGGGAGAAGAAGGGGCAGCACGCCAAGACGCTGGA
CGCTGACCTGATCCCGATCATCGAGGCGCTGGCATCCGACGAGCCGCTTGAACCGCGCCACCGCGACCATGCGCTGACCG
GCGACTGGCGCGACCATCGCGATTGCCACATAAAGCCCGACCTCGTGCTGATTTACCGCAAGCCCGATGACGACACCTTG
CAGCTTGTGCGCTTGGGATCGCACGCGGAATTGGGTTGGTGA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT178903 WP_000961810.1 NZ_CP063829:c1608827-1608375 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT178903 NZ_CP084408:113942-114205 [Sphingobium sp. CFD-2]
ATGGCCGCAAACGCTCTTGTGCAGACCCGGATCGACGGAGCGGTGAAGGAGGAAGCCGCGACCGTGCTGGCTGCTATGGG
GCTGACCGTCTCCGATGCCGTGCGCCTGATGCTGACCCGCGTTGCCCGCGACAAGGCCTTGCCGTTTGAACCGCTGGTGC
CCAATGCCGAGACGATCGAGGCCATGAAGGAAGCGCGCGAGGGAAAGGGCAAGCGGTTCGCCACGGTGGTCGACCTGATG
GCCGACCTCAATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
AlphaFold DB G0IC64

References