Detailed information of TA system TA178902

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 932123..932621
• Replicon: chromosome
• Accession: NZ_CP063829
• Organism: Streptococcus pneumoniae strain 19A-ST320_99-176

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IRE31_RS04775
• Protein ID: WP_001812387.1
• Coordinates: 932367..932621 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: IRE31_RS04770
• Protein ID: WP_000208080.1
• Coordinates: 932123..932365 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IRE31_RS04750 (IRE31_04710)	927945..929120	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
IRE31_RS04755 (IRE31_04715)	929175..929879	+	705	WP_000722076.1	response regulator YycF	-
IRE31_RS04760 (IRE31_04720)	929872..931221	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
IRE31_RS04765 (IRE31_04725)	931223..932032	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
IRE31_RS04770 (IRE31_04730)	932123..932365	+	243	WP_000208080.1	DUF6290 family protein	Antitoxin
IRE31_RS04775 (IRE31_04735)	932367..932621	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IRE31_RS04780 (IRE31_04740)	932668..933441	+	774	WP_000731129.1	ion channel	-
IRE31_RS04785 (IRE31_04745)	933757..935103	-	1347	WP_001814919.1	IS1380-like element ISSpn5 family transposase	-
IRE31_RS04790 (IRE31_04750)	935412..936398	-	987	WP_000204727.1	L-lactate dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	933757..935103	1346

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T178902 WP_001812387.1 NZ_CP063829:932367-932621 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T178902 NZ_CP084407:237494-237829 [Sphingobium sp. CFD-2]
ATGGTCAGTCGCTATCTGCCTGACACGGGCGATATCGTGTGGCTGCAATTCGATCCCCAAGCGGGGCATGAGCAAGCGGG
GCATCGGCCTGCCCTTGTGCTCTCACCTGCGGCCTATAACAAAACGCGGGGTATGATGATTTGCTGCCCGATGACGAGCC
AGATCAAGGGCTATCCTTTCGAAGTTGTTGTGTCCCGGGAACCGCCCAGCGTCGTCTTGTCCGATCAGATCAAGAGCCTT
GATTGGAAGGCGCGAGCGGCGAAGAAAAAGAGTTCTGTATCAACGGCAGTGATCGACGAGGTCCGCGCAAAGGTAGGCGC
ACTCCTCGGCATTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT178902 WP_000208080.1 NZ_CP063829:932123-932365 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT178902 NZ_CP084407:237252-237494 [Sphingobium sp. CFD-2]
ATGGGTGTTCAGGTAAAGAAGTGGGGTAATAGTGCGGCGATCCGCATCCCCTCCGCCATCATGGCGGCTGCTGCGCTGAA
TGTTGGACAGGAAGTCGAAGTTCGCGAAGAAGGCGGCCGGCTCATCATTGAACCCGTCTTGAAGCCTGTCTATACGCTCG
AGGGATTGCTAGCAGGCATGAAGCCGGAGACGTTCCACGACAACGTAGATTTTGGTCCCCCGGTCGGCAATGAGATATTT
TGA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7