Detailed information of TA system TA178901

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2770974..2771656
• Replicon: chromosome
• Accession: NZ_CP063815
• Organism: Microbacterium sp. A18JL241

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IM776_RS13380
• Protein ID: WP_194420572.1
• Coordinates: 2771207..2771656 (+)
• Length: 150 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IM776_RS13375
• Protein ID: WP_194420571.1
• Coordinates: 2770974..2771210 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IM776_RS13350	2767540..2768160	+	621	WP_194420566.1	hypothetical protein	-
IM776_RS13355	2768160..2768771	+	612	WP_194420567.1	hypothetical protein	-
IM776_RS13360	2768768..2769007	+	240	WP_194420568.1	helix-turn-helix domain-containing protein	-
IM776_RS13365	2769007..2769225	+	219	WP_194420569.1	hypothetical protein	-
IM776_RS13370	2769405..2770907	-	1503	WP_194420570.1	HNH endonuclease	-
IM776_RS13375	2770974..2771210	+	237	WP_194420571.1	ribbon-helix-helix domain-containing protein	Antitoxin
IM776_RS13380	2771207..2771656	+	450	WP_194420572.1	PIN domain-containing protein	Toxin
IM776_RS13385	2771957..2772130	-	174	WP_194420573.1	hypothetical protein	-
IM776_RS13390	2772275..2775070	-	2796	WP_194420574.1	DEAD/DEAH box helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (4-144)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 150 a.a.
• Molecular weight: 16134.39 Da
• Isoelectric Point: 6.8705

>T178901 WP_194420572.1 NZ_CP063815:2771207-2771656 [Microbacterium sp. A18JL241]
MTLVVPDVNVLVYAFRADSPDHDVYADWLNGAMRAGRIGVADTILSGFVRIVTHPRIYAEPTPVAAALAYVRHLIDAPNT
DWLRQGPSAWEKFDALASEDAAVRGNLVPDAHIAALCLANGARLATRDRGFARFPGLRLFDPAKADAGR

Nucleotide

• Length: 450 bp

>T178901 NZ_CP084407:c37472-37191 [Sphingobium sp. CFD-2]
ATGATACAGAGGGCCAAAGGGAAGTTGGTTGAACAGGTGTTGGTGGGCAAGCCGGGCAAAGGCTTCCCGGACGACTTCTT
CCGGGCTGCTGTGCGGAAGCTGGCTATGTTTGAGGCGGCGGTGAATCTGGACGACTTGCGGTCGCCTCCGGGCAACAGGC
TGGAAGCACTGTCCGATGACCGTGCGGGCCAGCATTCGATCCGGATCAACGACCAATGGCGTATCTGTTTCGTCTGGACC
GACAGAGGCCCGCAAGACGTAGAAATCGTGGATTATCATTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8637.69 Da
• Isoelectric Point: 4.7824

>AT178901 WP_194420571.1 NZ_CP063815:2770974-2771210 [Microbacterium sp. A18JL241]
MRTTLNLSDALAREAKSRAAREGRTFTSFLEEALREHLARELPDAPQTPLPTYTPKVPGSLVDLDDKDAVWDALDKSA

Nucleotide

• Length: 237 bp

>AT178901 NZ_CP084407:c37179-36892 [Sphingobium sp. CFD-2]
ATGACCATGTTGAAAACCCCGGTCCATCCCGGCGAAATCCTCAAGCATGAGTTCCTTGAGGAGATGGGCATTTCCGCTGG
CAAGCTGGCGAAGCATATCCATGTCCCCCGCACTCGCATCGAGCGGCTGTGCGAGGAGAGGACTTCGGTCACGCCGGACA
CGGCCAAGCGTCTGTCCAAGGCACTGGGTACGACGCCGGAGTTCTGGCTTAACCTCCAGACGCATTATGATTTGCTGATG
GACCAGGCCGCCGACATCGAAGAAATCAAGCCGCTGCTGGCGGCTTGA