Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2721839..2722488 Replicon chromosome
Accession NZ_CP063814
Organism Microbacterium sp. A18JL200

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IM777_RS13325 Protein ID WP_194385568.1
Coordinates 2722096..2722488 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IM777_RS13320 Protein ID WP_071045522.1
Coordinates 2721839..2722093 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM777_RS13300 2718160..2718627 + 468 WP_194383700.1 DUF805 domain-containing protein -
IM777_RS13305 2718865..2720736 - 1872 WP_194383701.1 hypothetical protein -
IM777_RS13310 2720816..2721136 + 321 WP_194383702.1 hypothetical protein -
IM777_RS13315 2721133..2721711 + 579 WP_071045523.1 hypothetical protein -
IM777_RS13320 2721839..2722093 + 255 WP_071045522.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IM777_RS13325 2722096..2722488 + 393 WP_194385568.1 type II toxin-antitoxin system VapC family toxin Toxin
IM777_RS13330 2722576..2723913 - 1338 WP_194383703.1 HNH endonuclease -
IM777_RS13335 2724268..2725755 - 1488 WP_194383704.1 sulfatase-like hydrolase/transferase -
IM777_RS13340 2725796..2726800 - 1005 WP_194383705.1 LacI family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-125)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13531.53 Da        Isoelectric Point: 7.8616

>T178900 WP_194385568.1 NZ_CP063814:2722096-2722488 [Microbacterium sp. A18JL200]
IAVDTSALMAIVLGERDALPFARALAANTGDACVSAATLVEATIVAEARQGSAAAQDLAAVLRETRIRIVPLDATQASIA
SAAWRRFGKGRHTAALNLGDCYSYALARHLGAPLLFKGDGFRQTDIAPVL

Download         Length: 393 bp

>T178900 NZ_CP084406:c971365-971033 [Sphingobium sp. CFD-2]
ATGGCCAAATATGTCCCCGACATGGGCGATATCGTCTGGCTAAACTTTGATCCCCAGGCTGGACATGAACAGGCTGGTCA
TCGACCTGCCCTTGTCCTGTCACCGGCAGCCTATAATCGCGTGCGCGGGATGATGATTTGTTGTCCTATGACAAGCAAAA
TCAAAGGCTATCCCTTTGAGGTGTTAACCAGCCAGAACCTGCCAAGTGCTGTATTGGCAGATCAGCTCAAAAGTGTTGAC
TGGATGACACGGAAGGCGACCAAAAAAGGAACAGTATCGCAAGCGGCGCTGCTGGAAGTTCAGGCAAAAATCCGTGCTCT
GTTGGCGATTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9065.14 Da        Isoelectric Point: 4.3030

>AT178900 WP_071045522.1 NZ_CP063814:2721839-2722093 [Microbacterium sp. A18JL200]
MALNIKDPEADRLARALAAATGESITVAARAAFAERLARVQARDTAPEVLAELESIIARARERETLDDRTTDEILGYDEA
GLPT

Download         Length: 255 bp

>AT178900 NZ_CP084406:c971607-971365 [Sphingobium sp. CFD-2]
ATGCGTGTGCGAGTGAAAAAGTGGGGTAATAGTGCTTCGGTCAGGATTCCTTCCTCGATTATGGCCGCGGCTGCGCTGCA
TATCGATCAGGAGGTGGATGTCAGGGAAGAAGAGGGCCGGGTCATCATCGAGCCGATCACCGCACCTGCCTTCACTCTTG
AGGGGTTGCTGGCGGGCATGAAGCCTGAAAACTTTCCTGAAAACGTCGATTTCGGTCCGCCTGTCGGCAATGAGCTTTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References