Detailed information of TA system TA178896

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 3769706..3770391
• Replicon: chromosome
• Accession: NZ_CP063804
• Organism: Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TIR9
• Locus tag: RJtmp_RS17755
• Protein ID: WP_003417998.1
• Coordinates: 3769981..3770391 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: RJtmp_RS17750
• Protein ID: WP_249739979.1
• Coordinates: 3769706..3769984 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RJtmp_RS17730 (RJtmp_003505)	3765695..3767296	-	1602	WP_003417969.1	FAD/NAD(P)-binding protein	-
RJtmp_RS17735 (RJtmp_003506)	3767313..3768017	-	705	WP_003417980.1	dTDP-4-amino-4,6-dideoxyglucose formyltransferase	-
RJtmp_RS17740 (RJtmp_003507)	3768135..3768701	-	567	WP_003417984.1	TetR/AcrR family transcriptional regulator	-
RJtmp_RS17745 (RJtmp_003508)	3768763..3769650	+	888	WP_003417989.1	alpha-ketoglutarate-dependent sulfate ester dioxygenase	-
RJtmp_RS17750 (RJtmp_003509)	3769706..3769984	+	279	WP_249739979.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
RJtmp_RS17755 (RJtmp_003510)	3769981..3770391	+	411	WP_003417998.1	type II toxin-antitoxin system VapC family toxin	Toxin
RJtmp_RS17760 (RJtmp_003511)	3770424..3772160	-	1737	WP_003418002.1	cholesterol oxidase	-
RJtmp_RS17765 (RJtmp_003512)	3772216..3773343	-	1128	WP_003418005.1	GuaB3 family IMP dehydrogenase-related protein	-
RJtmp_RS17770 (RJtmp_003513)	3773363..3774952	-	1590	WP_003418007.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-54)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14695.84 Da
• Isoelectric Point: 5.1784

>T178896 WP_003417998.1 NZ_CP063804:3769981-3770391 [Mycobacterium orygis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Nucleotide

• Length: 411 bp

>T178896 NZ_CP084405:c3104637-3104305 [Sphingobium sp. CFD-2]
ATGGCTGCTTATGTGCCGGATATCGGCGACATCGTTTGGCTGGAATTTGATCCTCAGGCCGGTCACGAACAGGCGGGACA
CCGTCCTGCTCTTGTTCTGTCGCCAGAGAAGTACAACGGCTTGCGTGGTATGATGATCTGCTGCCCTATGACAAGCAGGA
TCAAGGGCTATCCCTTCGAGGTAGTCGAAAGCCGTACTCCTCCGAGCGTCGTTCTCGCCGATCAGGTCAAGAGCCTGGAT
TGGAGAGCGCGTCGAGCGAGCAAGAAAGGCAAGATATCCCAGGCGGCGCTGGCGGAAGTCCAAGCGAAAATTCGCGCCTT
GCTGGCGTTGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10227.70 Da
• Isoelectric Point: 8.0222

>AT178896 WP_249739979.1 NZ_CP063804:3769706-3769984 [Mycobacterium orygis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPACGRKRT
LSDVLNEMRDEQ

Nucleotide

• Length: 279 bp

>AT178896 NZ_CP084405:c3104879-3104637 [Sphingobium sp. CFD-2]
ATGATGCGTGTTCAGGTCAAGAAATGGGGCAACAGTGCTTCGGTTCGGATTCCGGCGTCGATTATGGCTGCGGCAGCTCT
CCATATCGATCAGGAAGTGGATGTACGAGAGGAAGATGGACGCATTGTTATCGACCCTGTGATGCGGTCCTATAGTCTGG
ATGAGCTTTTGGCCAAGATGACGCCAGATACATTTCCCGATACGATCGAATTTGGAGCGCCGGTCGGAAATGAGTCCTGG
TAA

Structures

Toxin

• AlphaFold DB: G0TIR9