Detailed information of TA system TA178895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 3742487..3743154
• Replicon: chromosome
• Accession: NZ_CP063804
• Organism: Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: O50411
• Locus tag: RJtmp_RS17630
• Protein ID: WP_003417916.1
• Coordinates: 3742487..3742879 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0E8U8S7
• Locus tag: RJtmp_RS17635
• Protein ID: WP_003912214.1
• Coordinates: 3742879..3743154 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RJtmp_RS17615 (RJtmp_003482)	3737857..3739695	-	1839	WP_003918607.1	1-deoxy-D-xylulose-5-phosphate synthase	-
RJtmp_RS17620 (RJtmp_003483)	3739692..3740681	-	990	WP_003417912.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
RJtmp_RS17625 (RJtmp_003484)	3740681..3741733	-	1053	WP_003417914.1	polyprenyl synthetase family protein	-
RJtmp_RS17630 (RJtmp_003485)	3742487..3742879	-	393	WP_003417916.1	type II toxin-antitoxin system VapC family toxin	Toxin
RJtmp_RS17635 (RJtmp_003486)	3742879..3743154	-	276	WP_003912214.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
RJtmp_RS17640 (RJtmp_003487)	3743336..3744707	+	1372	Protein_3487	ISNCY family transposase	-
RJtmp_RS17645 (RJtmp_003488)	3744897..3747047	+	2151	WP_003417925.1	PE family protein	-
RJtmp_RS17650 (RJtmp_003489)	3747118..3747990	-	873	WP_003417929.1	3-hydroxyacyl-thioester dehydratase HtdY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3744030..3744707	677

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-53)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14316.74 Da
• Isoelectric Point: 10.7249

>T178895 WP_003417916.1 NZ_CP063804:c3742879-3742487 [Mycobacterium orygis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Nucleotide

• Length: 393 bp

>T178895 NZ_CP084405:c3010896-3010423 [Sphingobium sp. CFD-2]
GTGAGCCAATCCCTTTGGCGGATAGGCACAGATACGCGAAGCTATTCTGCGAGCGATCTCTCAGGCACTGGGGCAAAACT
CAGTGGAGGACGCTGGAACGATGAAGGTGTCGCGGTCGTCTATACTGCCAGCACCCGATCGCTGGCTTGCCTTGAAACCG
TCGTCCACCTCGCCGCTGACGAACTTCCGCTCAACCGGTATTTGGTCGAGGTGGTTGTCCCCGACGACATCTGGGGTGGG
GCTGAGCGTCTCGATCATCGTACTGCTCCAGTTGGGTGGGACGCCCACCCCGCAGGCATCGAGAGTACGGCTTACGGCAC
GGAGTGGGTGATCAGTCAAAGGACAGCGCTTCTCTTTGTCCCGTCAACGATCGTCCCCGAGGAACCGAACGTTCTCATCA
ACCCAGCCCATCCGGATGCCGCGCGTATAACCGCCACGAAGATACGCAAATGGATCTACGACCATAGGCTATAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9966.35 Da
• Isoelectric Point: 4.5332

>AT178895 WP_003912214.1 NZ_CP063804:c3743154-3742879 [Mycobacterium orygis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Nucleotide

• Length: 276 bp

>AT178895 NZ_CP084405:c3011375-3010893 [Sphingobium sp. CFD-2]
ATGATGACACGCGCTGGAACCGCCATCACGACGAAGGTCGAAGCCCCCACTGGGAATCTTGTGCCAATTGACCTCTTCCG
TGCCGGAGCGGCCGAAAAAATCGCCTTCATCAAGAAGGGGGTGCCCGCACGAACGGCCAAATATCTCATCAGGGGATTCA
ACCTCGACCAGAAGGTTATGCTCGATGCCCTGAGTCTGAAGACGGCGACGATCAATCGGAAGGCGACGAAAAATCAGGTA
CTCAGTGCCGATGAAAGTGAACGCGTCATCGGCTTGGCCGAGTTGCTTGGGCAGGTCGAAGCGATGGTCGAGGAGTCCGG
CAATCCCGAAGGTTTCGACGCTCGTACCTGGCTCGCCAATTGGCTGCGACGGCCTGTTCCGGCCTTAGGCGGTGCGAAGC
CCCTGGAATATCTCGACACCATGAAAGGGCAGATGCTCGTATCAAAGCTCCTTCAGCAGATGCAGACCGGAGCTTTTGCG
TGA

Structures

Toxin

• AlphaFold DB: A0A7U4BXS8

Antitoxin

• AlphaFold DB: A0A0E8U8S7