Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3715391..3715920 | Replicon | chromosome |
| Accession | NZ_CP063804 | ||
| Organism | Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | RJtmp_RS17510 | Protein ID | WP_003417760.1 |
| Coordinates | 3715663..3715920 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | RJtmp_RS17505 | Protein ID | WP_003417757.1 |
| Coordinates | 3715391..3715666 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RJtmp_RS17470 (RJtmp_04450) | 3711964..3712653 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
| RJtmp_RS17475 (RJtmp_04455) | 3712840..3713211 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| RJtmp_RS17480 (RJtmp_04460) | 3713109..3713327 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| RJtmp_RS17485 (RJtmp_04465) | 3713354..3713614 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| RJtmp_RS17490 (RJtmp_003457) | 3713729..3714118 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
| RJtmp_RS17495 (RJtmp_003458) | 3714132..3714425 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| RJtmp_RS17500 (RJtmp_003459) | 3714422..3715267 | - | 846 | WP_003417751.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| RJtmp_RS17505 (RJtmp_003460) | 3715391..3715666 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| RJtmp_RS17510 (RJtmp_003461) | 3715663..3715920 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| RJtmp_RS17515 (RJtmp_003462) | 3715962..3717152 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| RJtmp_RS17520 (RJtmp_003463) | 3717269..3717637 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| RJtmp_RS17525 (RJtmp_003464) | 3717634..3718185 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| RJtmp_RS17530 (RJtmp_003465) | 3718192..3718773 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| RJtmp_RS17535 (RJtmp_003466) | 3718754..3719122 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| RJtmp_RS17540 (RJtmp_003467) | 3719100..3719492 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T178894 WP_003417760.1 NZ_CP063804:3715663-3715920 [Mycobacterium orygis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T178894 NZ_CP084405:2159397-2159672 [Sphingobium sp. CFD-2]
ATGCCGCACGTCATCTGGCGCCCGAAGGCGCTCGAAGATGCCGACCGCATCATCGACTATATCTCCGACCGCAATCCCGC
CGCTGCCGCCCGCCTTGCCGATCTGTTCGAATATGCCGCTGAGCGACTGGCCGACCATCCCTATATGCATCGCGCCGGTC
GCGTCCCGGATACGCGGGAAGCCATCGTTACCCCCAACTACGTCCTCGTTTACCGCGCAGGCGCAGACGTCATCGAAATC
CTGGCCGTCCTCCACACCCGCCAACAATATCCTTGA
ATGCCGCACGTCATCTGGCGCCCGAAGGCGCTCGAAGATGCCGACCGCATCATCGACTATATCTCCGACCGCAATCCCGC
CGCTGCCGCCCGCCTTGCCGATCTGTTCGAATATGCCGCTGAGCGACTGGCCGACCATCCCTATATGCATCGCGCCGGTC
GCGTCCCGGATACGCGGGAAGCCATCGTTACCCCCAACTACGTCCTCGTTTACCGCGCAGGCGCAGACGTCATCGAAATC
CTGGCCGTCCTCCACACCCGCCAACAATATCCTTGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT178894 WP_003417757.1 NZ_CP063804:3715391-3715666 [Mycobacterium orygis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT178894 NZ_CP084405:2159215-2159397 [Sphingobium sp. CFD-2]
ATGACCAAACTCACTCCCATCGAGTCCGAGTTCGCGACCACCGAGGACGCCGAGGCTTATGACGCTTGGTTCCGCGCCAA
GGTCGAAGCCGCCTTGGCCGATCCCCGGCCCGGCATCCCGCACGATCAGGTCATGGCGAAACTGCGCGCCATCATTGAGG
CCAAGAAAGCCAAGCAGGCCTGA
ATGACCAAACTCACTCCCATCGAGTCCGAGTTCGCGACCACCGAGGACGCCGAGGCTTATGACGCTTGGTTCCGCGCCAA
GGTCGAAGCCGCCTTGGCCGATCCCCGGCCCGGCATCCCGCACGATCAGGTCATGGCGAAACTGCGCGCCATCATTGAGG
CCAAGAAAGCCAAGCAGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|