Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3646758..3647432 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag RJtmp_RS17300 Protein ID WP_003417282.1
Coordinates 3646758..3647186 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag RJtmp_RS17305 Protein ID WP_003417286.1
Coordinates 3647190..3647432 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS17275 (RJtmp_003417) 3642580..3642981 - 402 WP_003417264.1 cytidine deaminase -
RJtmp_RS17280 (RJtmp_003418) 3643218..3643556 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
RJtmp_RS17285 (RJtmp_003419) 3643553..3643987 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
RJtmp_RS17290 (RJtmp_003420) 3644116..3645888 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
RJtmp_RS17295 (RJtmp_003421) 3645888..3646679 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
RJtmp_RS17300 (RJtmp_003422) 3646758..3647186 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
RJtmp_RS17305 (RJtmp_003423) 3647190..3647432 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
RJtmp_RS17310 (RJtmp_003424) 3647554..3648168 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
RJtmp_RS17315 (RJtmp_003425) 3648165..3648830 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
RJtmp_RS17320 (RJtmp_003426) 3648831..3649364 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
RJtmp_RS17325 (RJtmp_003427) 3649361..3649735 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
RJtmp_RS17330 (RJtmp_003428) 3649832..3650968 - 1137 WP_003417297.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T178893 WP_003417282.1 NZ_CP063804:c3647186-3646758 [Mycobacterium orygis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T178893 NZ_CP084405:1797880-1798176 [Sphingobium sp. CFD-2]
ATGGCCTATAGACTCACGCGTAACGCCGAAAAGGATCTCATCGGTATATATGTCGGCGGCGTCGGAGAATTAGGAGAAGC
CGTCGCGGAAAAATATCAGGCCGGTTTGCATCGGGTTTTTGGATTTCTCTCCGACTTTCCCTATTCGGCAAGAGCGCGCG
CGGAAATTTCACCACCGGTCCGGGCACATCCCTACAAGTCCCATATCGTCGTCTATATCATCGAAGGACAGGACATCCTG
ATCCTCGGCGTCCGTCATGGACGGGAAGACTGGCAGGCATCCGACCAGCTTTCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT178893 WP_003417286.1 NZ_CP063804:c3647432-3647190 [Mycobacterium orygis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT178893 NZ_CP084405:1797639-1797890 [Sphingobium sp. CFD-2]
ATGGCGACAATGAATGTTTCCCTCCCCGATGCGATGAAGGAATGGGTCGAAGGTCAGGCCGGGACAGGCAGATACAGCAA
TGCCAGCGATTATGTGCGCGACCTGATCCGTCGCGACCAGGAGCGGCGGGAGAAGATCGCAGCCATGCAGACCATGGTCG
ATGAGTCTCTCGCCTCCGGCATAAGTCCCAATTCCATCGATGACATGATGAAGGAAGCCCGGCGTCGCGCAGGCGTCGGT
CATGGCCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References