Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3123791..3124339 Replicon chromosome
Accession NZ_CP063804
Organism Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag RJtmp_RS14945 Protein ID WP_003414602.1
Coordinates 3124076..3124339 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag RJtmp_RS14940 Protein ID WP_003414599.1
Coordinates 3123791..3124072 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJtmp_RS14915 (RJtmp_002951) 3119405..3120271 - 867 WP_003414581.1 type I methionyl aminopeptidase -
RJtmp_RS14920 (RJtmp_002952) 3120313..3120897 - 585 WP_003414585.1 DUF1707 domain-containing protein -
RJtmp_RS14925 (RJtmp_002953) 3121001..3121249 + 249 WP_003913411.1 antitoxin VapB23 -
RJtmp_RS14930 (RJtmp_002954) 3121246..3121626 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
RJtmp_RS14935 (RJtmp_002955) 3121708..3123519 - 1812 WP_003414596.1 penicillin-binding protein -
RJtmp_RS14940 (RJtmp_002956) 3123791..3124072 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
RJtmp_RS14945 (RJtmp_002957) 3124076..3124339 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RJtmp_RS14950 (RJtmp_002958) 3124712..3125566 - 855 WP_003414604.1 GNAT family N-acetyltransferase -
RJtmp_RS14955 (RJtmp_002959) 3125622..3126785 - 1164 WP_003414608.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
RJtmp_RS14960 (RJtmp_002960) 3126802..3128016 - 1215 WP_003414610.1 zinc metalloprotease Rip -
RJtmp_RS14965 (RJtmp_002961) 3128024..3129265 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T178891 WP_003414602.1 NZ_CP063804:3124076-3124339 [Mycobacterium orygis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T178891 NZ_CP084400:c97365-97084 [Sphingobium sp. CFD-1]
ATGCGGACGATTGAACGCTTCGGGCGGTTCAAGCGCGACTACAAGCGGGAGAAGAAGGGGCAGCACGCCAAGACGCTGGA
CGCTGACCTGATCCCGATCATCGAGGCGCTGGCATCCGACGAGCCGCTTGAACCGCGCCACCGCGACCATGCGCTGACCG
GCGACTGGCGCGACCATCGCGATTGCCACATAAAGCCCGACCTCGTGCTGATTTACCGCAAGCCCGATGACGACACCTTG
CAGCTTGTGCGCTTGGGATCGCACGCGGAATTGGGTTGGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT178891 WP_003414599.1 NZ_CP063804:3123791-3124072 [Mycobacterium orygis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT178891 NZ_CP084400:c97615-97352 [Sphingobium sp. CFD-1]
ATGGCCGCAAACGCTCTTGTGCAGACCCGGATCGACGGAGCGGTGAAGGAGGAAGCCGCGACCGTGCTGGCTGCTATGGG
GCTGACCGTCTCCGATGCCGTGCGCCTGATGCTGACCCGCGTTGCCCGCGACAAGGCCTTGCCGTTTGAACCGCTGGTGC
CCAATGCCGAGACGATCGAGGCCATGAAGGAAGCGCGCGAGGGAAAGGGCAAGCGGTTCGCCACGGTGGTCGACCTGATG
GCCGACCTCAATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References