Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 3079964..3081738 | Replicon | chromosome |
| Accession | NZ_CP063804 | ||
| Organism | Mycobacterium orygis strain MUHC/MB/EPTB/Orygis/51145 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | P71626 |
| Locus tag | RJtmp_RS14730 | Protein ID | WP_003414409.1 |
| Coordinates | 3079964..3080848 (-) | Length | 295 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | P71625 |
| Locus tag | RJtmp_RS14735 | Protein ID | WP_003414414.1 |
| Coordinates | 3080851..3081738 (-) | Length | 296 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RJtmp_RS14710 (RJtmp_002909) | 3075219..3075593 | - | 375 | WP_003414296.1 | type III-A CRISPR-associated protein Csm2 | - |
| RJtmp_RS14715 (RJtmp_002910) | 3075590..3078028 | - | 2439 | WP_003900580.1 | type III-A CRISPR-associated protein Cas10/Csm1 | - |
| RJtmp_RS14720 (RJtmp_002911) | 3078025..3078813 | - | 789 | WP_003917092.1 | CRISPR-associated endoribonuclease Cas6 | - |
| RJtmp_RS14725 (RJtmp_002912) | 3079147..3079692 | - | 546 | WP_003904931.1 | DUF1802 family protein | - |
| RJtmp_RS14730 (RJtmp_002913) | 3079964..3080848 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| RJtmp_RS14735 (RJtmp_002914) | 3080851..3081738 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| RJtmp_RS14740 (RJtmp_002915) | 3082043..3082588 | - | 546 | WP_003899500.1 | DUF1802 family protein | - |
| RJtmp_RS14745 (RJtmp_002916) | 3082585..3082854 | - | 270 | WP_003414489.1 | DUF2277 family protein | - |
| RJtmp_RS14750 (RJtmp_002917) | 3082875..3083267 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | - |
| RJtmp_RS14755 (RJtmp_002918) | 3083264..3083479 | - | 216 | WP_003414495.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| RJtmp_RS14760 (RJtmp_002919) | 3083526..3084275 | + | 750 | WP_003414497.1 | enoyl-CoA hydratase | - |
| RJtmp_RS14765 (RJtmp_002920) | 3084354..3085436 | - | 1083 | WP_003414499.1 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 295 a.a. Molecular weight: 33056.72 Da Isoelectric Point: 7.1520
>T178889 WP_003414409.1 NZ_CP063804:c3080848-3079964 [Mycobacterium orygis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
Download Length: 885 bp
>T178889 NZ_CP084398:2880194-2880487 [Sphingobium sp. CFD-1]
ATGAGGATTCAGTGGACCAGCAAGGCGTCGTCTGATCTTTTGCGCCTGCATGAGCATCTGCGGCCGGTCGCACCTGAGGC
AGCCGCGCGTATCGTGCAGCAGCTTGCACATGCGCCTGACCGCCTGCTCGACTATCCGCGCCTTGGCGAAAAGCTGGAGG
CCTTCGAACCCCGAGAAGTCCGTCGAATCATCGTGGGCCATTATGAAATGCGATACGAGATCGTAAGCGGAACCATCTTC
ATTCTCCGCCTTTGGCATTGTCGGGAGAACCGGAGCTTCGAAGCAGAGCATTGA
ATGAGGATTCAGTGGACCAGCAAGGCGTCGTCTGATCTTTTGCGCCTGCATGAGCATCTGCGGCCGGTCGCACCTGAGGC
AGCCGCGCGTATCGTGCAGCAGCTTGCACATGCGCCTGACCGCCTGCTCGACTATCCGCGCCTTGGCGAAAAGCTGGAGG
CCTTCGAACCCCGAGAAGTCCGTCGAATCATCGTGGGCCATTATGAAATGCGATACGAGATCGTAAGCGGAACCATCTTC
ATTCTCCGCCTTTGGCATTGTCGGGAGAACCGGAGCTTCGAAGCAGAGCATTGA
Antitoxin
Download Length: 296 a.a. Molecular weight: 32315.19 Da Isoelectric Point: 9.4723
>AT178889 WP_003414414.1 NZ_CP063804:c3081738-3080851 [Mycobacterium orygis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
Download Length: 888 bp
>AT178889 NZ_CP084398:2879928-2880197 [Sphingobium sp. CFD-1]
ATGGCAGCGGGAACCCGAGTTTTGACGGCCCATGTGCCGGAGGGGATGGCCGATAAGGTCGATGCCCTGGCCGCTCGCAT
CGAACGTTCGCGAGGGTGGATCATGAAGCAGGCTCTGGCGGCCTGGATCGACCAGGAGGAAGAGCGGCACAAGATGACGC
TGGAGGCCCTGGCGGATGTCGACGCGGGCCGGGTGATCGATCATCAGAGCATTCAGGCTTGGGCTGACAGCCTTTCGACG
GGCAGCCCGCTTCCCTCGCCCAGCGCATGA
ATGGCAGCGGGAACCCGAGTTTTGACGGCCCATGTGCCGGAGGGGATGGCCGATAAGGTCGATGCCCTGGCCGCTCGCAT
CGAACGTTCGCGAGGGTGGATCATGAAGCAGGCTCTGGCGGCCTGGATCGACCAGGAGGAAGAGCGGCACAAGATGACGC
TGGAGGCCCTGGCGGATGTCGACGCGGGCCGGGTGATCGATCATCAGAGCATTCAGGCTTGGGCTGACAGCCTTTCGACG
GGCAGCCCGCTTCCCTCGCCCAGCGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|